“Woah! It's like Spotify but for academic articles.”

Instant Access to Thousands of Journals for just $40/month

Get 2 Weeks Free

C-type natriuretic peptides stimulate chloride secretion in the rectal gland of Squalus acanthias

C-type natriuretic peptides stimulate chloride secretion in the rectal gland of Squalus acanthias AND P. SILVA New En Deaconess Hospital and Beth Israel Hospital, Boston, Massachusetts 02215; SCIOS, Mountain View, California 94043; and Mount Desert Island Biological Laboratory, Salsbury Cove, Maine 04672 Solomon, R., A. Protter, G.McEnroe, J. G. Porter, and P. Silva. C-type natriuretic peptides stimulate chloride secretion in of Squab acanthias. Am. J. Physiol. 262 (Regulatory Integrative Comp. Physiol. 31): R707R711, 1992.-Homologous shark C-type natriuretic peptide (sCNP) wasinfused asa bolusand asa constant infusion in the isolated perfused rectal of the same species,Squalus acanthias. sCNP was a potent stimulator of chloride secretion similar in its dose-response curve to vasoactive intestinal peptide. sCNP was equipotent with killifish CNP but more potent than human CNP (hCNP). Truncated and substituted, forms of hCNP were also capable of stimulation of chloride secretionin the order hCNP > hCNP (6-22) = [Glyg] hCNP > hCNP-( 7- 21). sCNP wasmorepotent than human atria1natriuretic peptide (hANP), which was more potent than porcine brain natriuretic peptide. hANP-(31-67) was without effect. These studiessuggest that sCNP may be the physiological regulator of rectal function. The receptor in is unknown but based the order of potencies,position 4 in the on NH,-terminal end and the ring itself are important for ligand effects. vasoactive http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Loading next page...
 
/lp/the-american-physiological-society/c-type-natriuretic-peptides-stimulate-chloride-secretion-in-the-rectal-Ujbu1B0tyT

You're reading a free preview. Subscribe to read the entire article.

And millions more from thousands of peer-reviewed journals, for just $40/month

Get 2 Weeks Free

To be the best researcher, you need access to the best research

  • With DeepDyve, you can stop worrying about how much articles cost, or if it's too much hassle to order — it's all at your fingertips. Your research is important and deserves the top content.
  • Read from thousands of the leading scholarly journals from Springer, Elsevier, Nature, IEEE, Wiley-Blackwell and more.
  • All the latest content is available, no embargo periods.

Stop missing out on the latest updates in your field

  • We’ll send you automatic email updates on the keywords and journals you tell us are most important to you.
  • There is a lot of content out there, so we help you sift through it and stay organized.