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Biochemical studies on opioid and alpha 2-adrenergic receptors in canine submucosal neurons

Biochemical studies on opioid and alpha 2-adrenergic receptors in canine submucosal neurons AHMAD, SULTAN, H.D. ALLESCHER, H. MANAKA,Y.MANAKA, E. E. DANIEL. Biochemical studies cy2adrenergic in canine neurs. Am. J. Physiol. 256 (Gastrointest. Liver Physiol. 19): G957-G965, 1989.Biochemical informati about for adrenergic neurotransmissi in (SMP) is unavailable. We have purified a fracti enriched in synaptosomes neural membranes (high [3H] saxitoxin binding high vasoactive intestinal polypeptide immunoreactivity, low activity of 5’-nucleotidase) from the canine small intestine SMP. The synaptosomal fracti (fracti ) also ctained a high density of diprenorphine binding sites of high affinity. [3H]rauwolscine binding was enriched both in fracti in a microsomal fracti. Competiti experiments using several adrenergic receptor ligs revealed that were approximately 64% p-, 24% 6-, 12% K-subtypes that adrenoceptors fracti were cy2subtype but that there was a heterogeneous populati of cy2adrenoceptors. These studies show that a fracti enriched in synaptosomes neural membranes from the canine intestine SMP ctains as well as a2-adrenoceptors, that all three subtypes of seem to be present with p- predominant, that subtypes of ac2-adrenoceptors appear to be present. ; phine; rauwolscine p-, 6-, K- ; diprenor- THE , also referred to as Meissner’s is a network of small ganglia cnecting fibers located between the circular muscle the muscularis mucosa of the gut (14). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Gastrointestinal and Liver Physiology The American Physiological Society

Biochemical studies on opioid and alpha 2-adrenergic receptors in canine submucosal neurons

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Publisher
The American Physiological Society
Copyright
Copyright © 1989 the American Physiological Society
ISSN
0193-1857
eISSN
1522-1547
Publisher site
See Article on Publisher Site

Abstract

AHMAD, SULTAN, H.D. ALLESCHER, H. MANAKA,Y.MANAKA, E. E. DANIEL. Biochemical studies cy2adrenergic in canine neurs. Am. J. Physiol. 256 (Gastrointest. Liver Physiol. 19): G957-G965, 1989.Biochemical informati about for adrenergic neurotransmissi in (SMP) is unavailable. We have purified a fracti enriched in synaptosomes neural membranes (high [3H] saxitoxin binding high vasoactive intestinal polypeptide immunoreactivity, low activity of 5’-nucleotidase) from the canine small intestine SMP. The synaptosomal fracti (fracti ) also ctained a high density of diprenorphine binding sites of high affinity. [3H]rauwolscine binding was enriched both in fracti in a microsomal fracti. Competiti experiments using several adrenergic receptor ligs revealed that were approximately 64% p-, 24% 6-, 12% K-subtypes that adrenoceptors fracti were cy2subtype but that there was a heterogeneous populati of cy2adrenoceptors. These studies show that a fracti enriched in synaptosomes neural membranes from the canine intestine SMP ctains as well as a2-adrenoceptors, that all three subtypes of seem to be present with p- predominant, that subtypes of ac2-adrenoceptors appear to be present. ; phine; rauwolscine p-, 6-, K- ; diprenor- THE , also referred to as Meissner’s is a network of small ganglia cnecting fibers located between the circular muscle the muscularis mucosa of the gut (14).

Journal

AJP - Gastrointestinal and Liver PhysiologyThe American Physiological Society

Published: Jun 1, 1989

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