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Baroreceptor control of pressure-flow relationships during hypoxemia

Baroreceptor control of pressure-flow relationships during hypoxemia of pressure-flow R. H. COX, G. KARREMAN, AND J. NEWSWANGER Irtstitute, of Anesthesiology of Pennsylvania, and Physiology and Bockus Research Philadelphia, Pennsylvania 19104 BAGSHAW, R. J., R. H. Cox, G. KARREMAN, AND J. NEWSBuroreceptor of pressure-flow relationships . J. Appl. Physiol. 60(1):166-175, 1986.-In WANGER. the absenceof peripheral chemoreceptors, effects of graded the on the carotid sinus of central and regional hemodynamicswere studied in anesthetizedmongrel dogs. stimulation was effected by carotid sinus isolation and perfusion under led pressure. Blood flows were measured the aorta and the celiac, mesenteric,left renal, and in right iliac arteries. Carotid sinusreflex set-point pressures were well maintained until was severe. Carotid sinus reflex set-point gain was maximal mild . Reflex operating point regional flows were unaffected by . A factorial analysisof overall reflex increases mean in aortic pressure,flow, and power reduced stimulation showedpotentiation by increasing. Correspondingeffects of stimulation and on aortic resistanceand heart rate were additive. Celiac, renal, and iliac blood flows increased both and reduced stimulation. Only in the celiac bed were blood flow changes independent of concomitant changes in cardiac output. Thus, at maximum sympathetic stimulation (low carotid sinus pressure) , the system maintained both central and regional blood flows at high systemicblood http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Baroreceptor control of pressure-flow relationships during hypoxemia

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Publisher
The American Physiological Society
Copyright
Copyright © 1986 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
See Article on Publisher Site

Abstract

of pressure-flow R. H. COX, G. KARREMAN, AND J. NEWSWANGER Irtstitute, of Anesthesiology of Pennsylvania, and Physiology and Bockus Research Philadelphia, Pennsylvania 19104 BAGSHAW, R. J., R. H. Cox, G. KARREMAN, AND J. NEWSBuroreceptor of pressure-flow relationships . J. Appl. Physiol. 60(1):166-175, 1986.-In WANGER. the absenceof peripheral chemoreceptors, effects of graded the on the carotid sinus of central and regional hemodynamicswere studied in anesthetizedmongrel dogs. stimulation was effected by carotid sinus isolation and perfusion under led pressure. Blood flows were measured the aorta and the celiac, mesenteric,left renal, and in right iliac arteries. Carotid sinusreflex set-point pressures were well maintained until was severe. Carotid sinus reflex set-point gain was maximal mild . Reflex operating point regional flows were unaffected by . A factorial analysisof overall reflex increases mean in aortic pressure,flow, and power reduced stimulation showedpotentiation by increasing. Correspondingeffects of stimulation and on aortic resistanceand heart rate were additive. Celiac, renal, and iliac blood flows increased both and reduced stimulation. Only in the celiac bed were blood flow changes independent of concomitant changes in cardiac output. Thus, at maximum sympathetic stimulation (low carotid sinus pressure) , the system maintained both central and regional blood flows at high systemicblood

Journal

Journal of Applied PhysiologyThe American Physiological Society

Published: Jan 1, 1986

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