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R-m Liu, K. Pravia (2010)
Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis.Free radical biology & medicine, 48 1
P. Li, M. Chappell, C. Ferrario, K. Brosnihan (1997)
Angiotensin-(1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide.Hypertension, 29 1 Pt 2
K. Brosnihan, P. Li, C. Ferrario (1996)
Angiotensin-(1-7) dilates canine coronary arteries through kinins and nitric oxide.Hypertension, 27 3 Pt 2
M. Satoh, S. Fujimoto, Yoshisuke Haruna, Sayaka Arakawa, H. Horike, N. Komai, Tamaki Sasaki, K. Tsujioka, H. Makino, N. Kashihara (2005)
NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy.American journal of physiology. Renal physiology, 288 6
S. Wassmann, U. Laufs, K. Müller, C. Konkol, K. Ahlbory, A. Bäumer, W. Linz, M. Böhm, G. Nickenig (2002)
Cellular Antioxidant Effects of Atorvastatin In Vitro and In VivoArteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association, 22
T. Hannken, R. Schroeder, G. Zahner, R. Stahl, G. Wolf (2000)
Reactive oxygen species stimulate p44/42 mitogen-activated protein kinase and induce p27(Kip1): role in angiotensin II-mediated hypertrophy of proximal tubular cells.Journal of the American Society of Nephrology : JASN, 11 8
C. Pawloski, G. Fink (1990)
Circulating angiotensin II and drinking behavior in rats.The American journal of physiology, 259 3 Pt 2
E. Ritz, V. Haxsen (2003)
Angiotensin II and oxidative stress: an unholy alliance.Journal of the American Society of Nephrology : JASN, 14 11
J. Zimpelmann, K. Burns (2009)
Angiotensin-(1-7) activates growth-stimulatory pathways in human mesangial cells.American journal of physiology. Renal physiology, 296 2
T. Hannken, R. Schroeder, G. Zahner, R. Stahl, G. Wolf (2000)
Reactive Oxygen Species Stimulate p44/42 Mitogen-Activated Protein Kinase and Induce p27Kip1 Role in Angiotensin II-Mediated Hypertrophy of Proximal Tubular CellsJournal of The American Society of Nephrology, 11
Eric Haugen, A. Croatt, Karl Nath (2000)
Angiotensin II induces renal oxidant stress in vivo and heme oxygenase-1 in vivo and in vitro.Kidney international, 58 1
Takamichi Ito, M. Tanimoto, Kaori Yamada, S. Kaneko, M. Matsumoto, Keiko Obayashi, Shinji Hagiwara, Maki Murakoshi, Tatsuya Aoki, M. Wakabayashi, T. Gohda, K. Funabiki, Kunimi Maeda, S. Horikoshi, Y. Tomino (2006)
Glomerular changes in the KK‐Ay/Ta mouse: A possible model for human type 2 diabetic nephropathyNephrology, 11
T. Guzik, S. Mussa, D. Gastaldi, J. Sadowski, C. Ratnatunga, R. Pillai, K. Channon (2002)
Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus: Role of NAD(P)H Oxidase and Endothelial Nitric Oxide SynthaseCirculation: Journal of the American Heart Association, 105
D. Diz, P. Baer, A. Nasjletti (1983)
Angiotensin II-induced hypertension in the rat. Effects on the plasma concentration, renal excretion, and tissue release of prostaglandins.The Journal of clinical investigation, 72 2
M. Matsumoto, M. Tanimoto, T. Gohda, Tatsuya Aoki, Maki Murakoshi, Kaori Yamada, Takahiko Yamazaki, S. Kaneko, S. Horikoshi, Y. Tomino (2008)
Effect of pitavastatin on type 2 diabetes mellitus nephropathy in KK-Ay/Ta mice.Metabolism: clinical and experimental, 57 5
Y. Shao, M. He, Li Zhou, T. Yao, Yu Huang, Li-min Lu (2008)
Chronic angiotensin (1–7) injection accelerates STZ-induced diabetic renal injuryActa Pharmacologica Sinica, 29
K. Kohara, K. Brosnihan, C. Ferrario, A. Milsted (1992)
Peripheral and central angiotensin II regulates expression of genes of the renin-angiotensin system.The American journal of physiology, 262 5 Pt 1
P. Xu, A. Costa-Goncalves, M. Todiras, L. Rabelo, W. Sampaio, Marina Moura, Sergio Santos, F. Luft, M. Bader, V. Gross, N. Alenina, R. Santos (2008)
Endothelial Dysfunction and Elevated Blood Pressure in Mas Gene-Deleted MiceHypertension, 51
W. Sampaio, C. Castro, R. Santos, E. Schiffrin, R. Touyz (2007)
Angiotensin-(1-7) Counterregulates Angiotensin II Signaling in Human Endothelial CellsHypertension, 50
M. Ye, J. Wysocki, Josette William, M. Soler, Ivan Cokic, D. Batlle (2006)
Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes.Journal of the American Society of Nephrology : JASN, 17 11
J. Baynes, S. Thorpe (1999)
Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.Diabetes, 48 1
M. Dharmani, M. Mustafa, F. Achike, M. Sim (2007)
Effects of angiotensin 1-7 on the actions of angiotensin II in the renal and mesenteric vasculature of hypertensive and streptozotocin-induced diabetic rats.European journal of pharmacology, 561 1-3
G. Wolf (2000)
Free radical production and angiotensinCurrent Hypertension Reports, 2
Pritmohinder Gill, C. Wilcox (2006)
NADPH oxidases in the kidney.Antioxidants & redox signaling, 8 9-10
I. Benter, M. Yousif, G. Dhaunsi, J. Kaur, M. Chappell, D. Diz (2007)
Angiotensin-(1–7) Prevents Activation of NADPH Oxidase and Renal Vascular Dysfunction in Diabetic Hypertensive RatsAmerican Journal of Nephrology, 28
Y. Ozawa, H. Kobori (2007)
Crucial role of Rho-nuclear factor-kappaB axis in angiotensin II-induced renal injury.American journal of physiology. Renal physiology, 293 1
Ningjun Li, J. Zimpelmann, K. Cheng, J. Wilkins, K. Burns (2005)
The role of angiotensin converting enzyme 2 in the generation of angiotensin 1-7 by rat proximal tubules.American journal of physiology. Renal physiology, 288 2
K. Brosnihan, L. Neves, J. Joyner, D. Averill, M. Chappell, R. Sarao, J. Penninger, C. Ferrario (2003)
Enhanced Renal Immunocytochemical Expression of ANG-(1-7) and ACE2 During PregnancyHypertension: Journal of the American Heart Association, 42
G. Cheng, B. Diebold, Y. Hughes, David Lambeth (2006)
Nox1-dependent Reactive Oxygen Generation Is Regulated by Rac1*Journal of Biological Chemistry, 281
U. Hink, N. Tsilimingas, M. Wendt, T. Münzel (2001)
Mechanisms Underlying Endothelial Dysfunction in Diabetes MellitusTreatments in Endocrinology, 2
Arnold Baas, B. Berk (1995)
Differential activation of mitogen-activated protein kinases by H2O2 and O2- in vascular smooth muscle cells.Circulation research, 77 1
Z. Su, J. Zimpelmann, Kevin Burns (2006)
Angiotensin-(1-7) inhibits angiotensin II-stimulated phosphorylation of MAP kinases in proximal tubular cells.Kidney international, 69 12
Denise D'Andrea, Brigitte Coupaye-Gerard, Thomas Kleyman, Mary Foster, M. Madaio (1996)
Lupus autoantibodies interact directly with distinct glomerular and vascular cell surface antigens.Kidney international, 49 5
W. Sampaio, R. Santos, Raphael Faria-Silva, L. Machado, E. Schiffrin, R. Touyz (2007)
Angiotensin-(1-7) Through Receptor Mas Mediates Endothelial Nitric Oxide Synthase Activation via Akt-Dependent PathwaysHypertension, 49
J. Baynes (1991)
Role of Oxidative Stress in Development of Complications in DiabetesDiabetes, 40
M. Okazaki, Yukako Saito, Yuko Udaka, M. Maruyama, Hidetomo Murakami, S. Ota, T. Kikuchi, K. Oguchi (2002)
Diabetic nephropathy in KK and KK-Ay mice.Experimental animals, 51 2
P. Dandona, S. Dhindsa, H. Ghanim, A. Chaudhuri (2007)
Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockadeJournal of Human Hypertension, 21
Shawn Hingtgen, Xin Tian, Jusan Yang, S. Dunlay, A. Peek, Yihe Wu, Ram Sharma, J. Engelhardt, R. Davisson (2006)
Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy.Physiological genomics, 26 3
Y. Ozawa, H. Kobori, Y. Suzaki, L. Gabriel, Ozawa Y, Kobori Suzaki, Navar Sustained, H. Kobori (2007)
Sustained renal interstitial macrophage infiltration following chronic angiotensin II infusions.American journal of physiology. Renal physiology, 292 1
K. Grote, M. Ortmann, G. Salguero, C. Doerries, U. Landmesser, M. Luchtefeld, R. Brandes, W. Gwinner, T. Tschernig, E. Brabant, A. Klos, A. Schaefer, H. Drexler, B. Schieffer (2006)
Critical role for p47phox in renin-angiotensin system activation and blood pressure regulation.Cardiovascular research, 71 3
N. Akis, M. Madaio (2004)
Isolation, culture, and characterization of endothelial cells from mouse glomeruli.Kidney international, 65 6
I. Benter, M. Yousif, C. Cojocel, M. Al-Maghrebi, D. Diz (2007)
Angiotensin-(1-7) prevents diabetes-induced cardiovascular dysfunction.American journal of physiology. Heart and circulatory physiology, 292 1
I. Benter, M. Yousif, J. Anim, C. Cojocel, D. Diz (2006)
Angiotensin-(1-7) prevents development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME.American journal of physiology. Heart and circulatory physiology, 290 2
M. Thomas, D. Gavrila, M. McCormick, F. Miller, A. Daugherty, L. Cassis, K. Dellsperger, N. Weintraub (2006)
Deletion of p47phox Attenuates Angiotensin II–Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E–Deficient MiceCirculation, 114
Abstract ANG-(1–7) is associated with vasodilation and nitric oxide synthase stimulation. However, the role of ANG-(1–7) in type 2 diabetes mellitus is unknown. In this study, we examined the hypothesis that ANG-(1–7) attenuates ANG II-induced reactive oxygen species stress (ROS)-mediated injury in type 2 diabetic nephropathy of KK-A y /Ta mice. KK-A y /Ta mice were divided into four groups: 1 ) a control group; 2 ) ANG II infusion group; 3 ) ANG II+ANG-(1–7) coinfusion group; and 4 ) ANG II+ANG-(1–7)+ d -Ala 7 -ANG-(1–7) (A779) coinfusion group. In addition, primary mesangial cells were cultured and then stimulated with 25 mM glucose with or without ANG II, ANG-(1–7), and A779. The ANG II+ANG-(1–7) coinfusion group showed a lower urinary albumin/creatinine ratio increase than the ANG II group. ANG-(1–7) attenuated ANG II-mediated NAD(P)H oxidase activation and ROS production in diabetic glomeruli and mesangial cells. ANG II-induced NF-κB and MAPK signaling activation was also attenuated by ANG-(1–7) in the mesangial cells. These findings were related to improved mesangial expansion and to fibronectin and transforming growth factor-β1 production in response to ANG II and suggest that ANG-(1–7) may attenuate ANG II-stimulated ROS-mediated injury in type 2 diabetic nephropathy. The ACE2-ANG-(1–7)-Mas receptor axis should be investigated as a novel target for treatment of type 2 diabetic nephropathy. Copyright © 2011 the American Physiological Society
AJP - Renal Physiology – The American Physiological Society
Published: Jun 1, 2011
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