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Indiana JAMES A. LEMONS RICHARD L. SCHREINER Section of Neonatal-Perinatal Medicine, Department of Pediatrics, University School of Medicine James Whitcomb Riley Hospital for Children, Indianapolis, Indiana LEMONS, JAMES A., RICHARD L. SCHREINER. in the ovine fetus. Am. J. Physiol. 244 (Endocrinol. Metab. 7): E459-E466, 1983.-Quantitative measurements of the umbilical uptake of a variety of substrates were made in the ovine fetus in both the fed state after 5 days of maternal fasting. Blood flow was measured in both study periods using the antipyrine method, with the simultaneous measurement of umbilical vein arterial concentrations of glucose, oxygen, 25 s in whole blood. Umbilical blood flow oxygen consumption remained unchanged between the fed fasted states. Umbilical glucose uptake decreased from a mean of 6.85 to 2.79 mg kg-â emin-â with a concomitant fall in the glucose:oxygen quotient from a mean of 0.70 to 0.31. Whereas the majority of gluconeogenic s decreased in concentration in the maternal circulation during fasting, the branched-chain s, as well as 3-methylhistidine, increased. In contrast the majority of s in the arterial circulation either increased significantly or remained unchanged in concentration. Although the excretion of urea increased by 70% during the period of maternal fasting, the
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: May 1, 1983
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