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Alveolar enlargement in obesity-induced hyperplastic lung growth

Alveolar enlargement in obesity-induced hyperplastic lung growth MATERIALS AND METHODS OBESITY alters biochemical an functional properties the lung, resultg pulmonary cellular hyperplasia, metabolic alterations lung composition, and abnormalities lung mechanics (1, 13). However, structural changes the lung duced by obesity have not been vestigated. Sce malnutrition causes suppression lung growth with alterations pulmonary parenchyma (15, ZO), it is possible that, addition to stimulation lung growth metabolically, obesity can modify pulmonary morphology as well. The present morphometric study was performed to quantitatively analyze structural characteristics alveoli durg hyperplastic lung growth occurrg with dietary-duced obesity young . 0161~7567,438 $1.50 Copyright Experimental design and animals. Obesity was duced -62 male newborn Long-Evans [Crl:(LE)BR, Charles River Breedg Laboratories, Kgston, NY], as previously described detail (13). Briefly, two to three male pups were nursed per mother and then fed ad libitum mouse chow (Pura Ralston no. 1015, St. Louis, MO), half-strength condensed milk (Borden, Columbus, OH), and water while s were nursed at 12 pups/ mother and then fed ad libitum rat chow (Pura Ralston no. 5001) and water. The were killed at 8 wk age, and body length, fat pad weight, and serum sul and glucose concentrations were determed, as previously reported (1.1, 13). The age 8 wk was http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Alveolar enlargement in obesity-induced hyperplastic lung growth

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Publisher
The American Physiological Society
Copyright
Copyright © 1988 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
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Abstract

MATERIALS AND METHODS OBESITY alters biochemical an functional properties the lung, resultg pulmonary cellular hyperplasia, metabolic alterations lung composition, and abnormalities lung mechanics (1, 13). However, structural changes the lung duced by obesity have not been vestigated. Sce malnutrition causes suppression lung growth with alterations pulmonary parenchyma (15, ZO), it is possible that, addition to stimulation lung growth metabolically, obesity can modify pulmonary morphology as well. The present morphometric study was performed to quantitatively analyze structural characteristics alveoli durg hyperplastic lung growth occurrg with dietary-duced obesity young . 0161~7567,438 $1.50 Copyright Experimental design and animals. Obesity was duced -62 male newborn Long-Evans [Crl:(LE)BR, Charles River Breedg Laboratories, Kgston, NY], as previously described detail (13). Briefly, two to three male pups were nursed per mother and then fed ad libitum mouse chow (Pura Ralston no. 1015, St. Louis, MO), half-strength condensed milk (Borden, Columbus, OH), and water while s were nursed at 12 pups/ mother and then fed ad libitum rat chow (Pura Ralston no. 5001) and water. The were killed at 8 wk age, and body length, fat pad weight, and serum sul and glucose concentrations were determed, as previously reported (1.1, 13). The age 8 wk was

Journal

Journal of Applied Physiology – The American Physiological Society

Published: Nov 1, 1988

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