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Alpha-adrenergic receptors in human and canine tracheal and bronchial smooth muscle

Alpha-adrenergic receptors in human and canine tracheal and bronchial smooth muscle KNEUSSL, M. P., J. B. RICHARDSON. AZpha-adrenergic receptors in human canine tracheal bronchial smooth muscle, J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 45(Z): 307-311, 1978. -We studied the reactions of human tracheal bronchial smooth muscle canine trachealis muscle to adrenergic agonists. Human tissue was obtained from recent autopsies of patients with normal lungs patients with respiratory disorders, canine tissue was obtained from animals used in other experiments. The muscle was mounted in tissue baths fitted with platinum wire electrodes the mechanical activity was recorded. Norepinephrine added to the normal human or canine tissue in concentrations up to 10S5 M caused no reaction. In the normal human in the dog, pretreatment with histamine or KC1 changed this response when norepinephrine was added the tissues contracted. This contraction was blocked by phentolamine or N,N’-bis-( O-methoxybenzylaminohexyX)-cystamine tetrahydrochloride (BHC). In diseased tissue, the addition of norepinephrine resulted in a contraction that was blocked by phentolamine or BHC no pretreatment with histamine or KC1 was required. These findings demonstrate a-receptors in human canine airway smooth muscle, there is a difference between normal diseased human tissue in the reaction of these tissues to a-adrenergic agonists. smooth muscle; airways; asthma; bronchoconstriction In the dog, the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Alpha-adrenergic receptors in human and canine tracheal and bronchial smooth muscle

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Publisher
The American Physiological Society
Copyright
Copyright © 1978 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
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Abstract

KNEUSSL, M. P., J. B. RICHARDSON. AZpha-adrenergic receptors in human canine tracheal bronchial smooth muscle, J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 45(Z): 307-311, 1978. -We studied the reactions of human tracheal bronchial smooth muscle canine trachealis muscle to adrenergic agonists. Human tissue was obtained from recent autopsies of patients with normal lungs patients with respiratory disorders, canine tissue was obtained from animals used in other experiments. The muscle was mounted in tissue baths fitted with platinum wire electrodes the mechanical activity was recorded. Norepinephrine added to the normal human or canine tissue in concentrations up to 10S5 M caused no reaction. In the normal human in the dog, pretreatment with histamine or KC1 changed this response when norepinephrine was added the tissues contracted. This contraction was blocked by phentolamine or N,N’-bis-( O-methoxybenzylaminohexyX)-cystamine tetrahydrochloride (BHC). In diseased tissue, the addition of norepinephrine resulted in a contraction that was blocked by phentolamine or BHC no pretreatment with histamine or KC1 was required. These findings demonstrate a-receptors in human canine airway smooth muscle, there is a difference between normal diseased human tissue in the reaction of these tissues to a-adrenergic agonists. smooth muscle; airways; asthma; bronchoconstriction In the dog, the

Journal

Journal of Applied Physiology – The American Physiological Society

Published: Aug 1, 1978

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