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Adaptation to prolonged starvation in the rat: curtailment of skeletal muscle proteolysis

Adaptation to prolonged starvation in the rat: curtailment of skeletal muscle proteolysis MICHAELN., MARY A. NEIL B. RUDERMAN. Adaptation to prolonged starvation in the rat: curtaihtent of sheZeta muscle proteolysis. Am. J. Physiol. 241 (Endocrinol. Metab. 4): E321-E327, 1981.-Previous studies have established that 16-wk- nonobese obese rats conserve body protein during prolonged starvation. To determine the basis for this, protein synthesis degradation in muscle were evaluated in the isolated perfused hindquarters of these rats, in the fed state when starved for 2, 5, 10, 11 days. Rats aged 4 8 wk were used as a comparison. The results indicate that the response to starvation depends on several factors: the age of the rat, its degree of adiposity, the duration of the fast. An early event in starvation was a decline in muscle protein synthesis. This occurred in all groups, albeit this reduction occurred more slowly in the er rats. A later response to starvation was an increase in muscle proteolysis. This occurred between 2 5 days in the &wk- rats. In 16-wk- rats it did not occur until between 5 10 days, it was preceded by a period of decreased proteolysis. In 16wk- obese rats, a decrease in proteolysis persisted for upwards of 10 days the secondary increase was not http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Adaptation to prolonged starvation in the rat: curtailment of skeletal muscle proteolysis

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Publisher
The American Physiological Society
Copyright
Copyright © 1981 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
Publisher site
See Article on Publisher Site

Abstract

MICHAELN., MARY A. NEIL B. RUDERMAN. Adaptation to prolonged starvation in the rat: curtaihtent of sheZeta muscle proteolysis. Am. J. Physiol. 241 (Endocrinol. Metab. 4): E321-E327, 1981.-Previous studies have established that 16-wk- nonobese obese rats conserve body protein during prolonged starvation. To determine the basis for this, protein synthesis degradation in muscle were evaluated in the isolated perfused hindquarters of these rats, in the fed state when starved for 2, 5, 10, 11 days. Rats aged 4 8 wk were used as a comparison. The results indicate that the response to starvation depends on several factors: the age of the rat, its degree of adiposity, the duration of the fast. An early event in starvation was a decline in muscle protein synthesis. This occurred in all groups, albeit this reduction occurred more slowly in the er rats. A later response to starvation was an increase in muscle proteolysis. This occurred between 2 5 days in the &wk- rats. In 16-wk- rats it did not occur until between 5 10 days, it was preceded by a period of decreased proteolysis. In 16wk- obese rats, a decrease in proteolysis persisted for upwards of 10 days the secondary increase was not

Journal

AJP - Endocrinology and MetabolismThe American Physiological Society

Published: Oct 1, 1981

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