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Active hepatic capacitance responses to neural and humoral stimuli in dogs

Active hepatic capacitance responses to neural and humoral stimuli in dogs TOM D., CARO. CARL F. responses to neural humoral stimuli in dogs. Am. J. Physiol. 242 (Heart Circ. Physiol. 11): HlOOO-H1009, 1982.- changes in were studied in pump-perfused dog livers during nerve stimulation or during intra arterial infusion of histamine (0.01-l mg/l) or epinephrine (0.05 mg/l). nerve stimulation at 5 pulses/s (pps) reduced blood volume by 76 t 39 (SD) ml/kg tissue decreased the apparent compliance 36% from a control value of 25.6 t 9.3 ml kg-’ mmHg-‘, with constant flow perfusion. With a constant arterial pressure, 5 pps stimulation decreased arterial flow to 16% of control; the volume expelled was 91 t 33 ml/kg. Epinephrine caused artery constriction, the expulsion of 71 ml/kg of blood, a decrease of about 30% in compliance. Histamine dramatically reduced the vascular compliance, decreased the portal venous conductance, increased arterial conductance, caused the apparent blood volume to double. Increased venous pressure, nerve stimulation, epinephrine, , especially, histamine caused a significant filtration of fluid from the vasculature. We conclude that significant changes transsinusoidal fluid filtration can be induced in the canine liver by neural hormonal stimuli. . compliance; venoconstriction; histamine; epinephrine; filtration; sympathetic nerve stimulation; integral of inflow minus outflow; conductance; resistance; passive http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Active hepatic capacitance responses to neural and humoral stimuli in dogs

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Publisher
The American Physiological Society
Copyright
Copyright © 1982 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
See Article on Publisher Site

Abstract

TOM D., CARO. CARL F. responses to neural humoral stimuli in dogs. Am. J. Physiol. 242 (Heart Circ. Physiol. 11): HlOOO-H1009, 1982.- changes in were studied in pump-perfused dog livers during nerve stimulation or during intra arterial infusion of histamine (0.01-l mg/l) or epinephrine (0.05 mg/l). nerve stimulation at 5 pulses/s (pps) reduced blood volume by 76 t 39 (SD) ml/kg tissue decreased the apparent compliance 36% from a control value of 25.6 t 9.3 ml kg-’ mmHg-‘, with constant flow perfusion. With a constant arterial pressure, 5 pps stimulation decreased arterial flow to 16% of control; the volume expelled was 91 t 33 ml/kg. Epinephrine caused artery constriction, the expulsion of 71 ml/kg of blood, a decrease of about 30% in compliance. Histamine dramatically reduced the vascular compliance, decreased the portal venous conductance, increased arterial conductance, caused the apparent blood volume to double. Increased venous pressure, nerve stimulation, epinephrine, , especially, histamine caused a significant filtration of fluid from the vasculature. We conclude that significant changes transsinusoidal fluid filtration can be induced in the canine liver by neural hormonal stimuli. . compliance; venoconstriction; histamine; epinephrine; filtration; sympathetic nerve stimulation; integral of inflow minus outflow; conductance; resistance; passive

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Jun 1, 1982

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