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Department of Pharmacology and the Cancer Center, and Department of Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 Haymes, Allyson A., Yiu Wa Kwan, Joseph P. Arena, Robert S. Kass, and Patricia M. Hinkle. Activation of C reduces L-type calcium channel activity of GH3 pituitary cells. Am. J. Physiol. 262 (CeZlPhysiol. 31): C1211-C1219, 1992.-These studies describe the effect of C (PKC) activation on the activity of -sensitive L-type Ca 2+ of GH3 pituitary cells. The rate of 45Ca2+ uptake was stimulated >25-fold by depolarization in the presence of BAY K 8644; the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) reduced this response by 70% in a concentration-dependent fashion. Phorbol12,13-dibutyrate (PDBu) inhibited depolarization-induced 45Ca2+ uptake within 1 min and caused a nearly maximal reduction after 1 h; its effects were rapidly reversible. TPA decreased the high K+stimulated increase in intracellular free calcium ion concentration ([Caâ+]i) from 8.5- to 3.2fold by 5 min and to 2.O-fold after 18 h without altering the peak [Ca2+]i response to the peptide hormone TRH. Ca2+ channel current, measured directly using the whole cell configuration of the patch-clamp technique, declined an average of 6.4% over 5 min for control cells and 28.9%
AJP - Cell Physiology – The American Physiological Society
Published: May 1, 1992
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