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Action of thyrotropin-releasing hormone on mammotrophs and thyrotrophs

Action of thyrotropin-releasing hormone on mammotrophs and thyrotrophs C. P. S. M. University Texas Health Science Center, Dallas, Texas 75235 G. 2. C. P. S. M. . thyrotropin-releasing hormone on mammotrophs thyrotrophs. Am. J. Physiol. 241 (Endocrinol. Metab. 4): E298-E304, 1981.-Anterior pituitary cells from 15-day-old female rats were separated by unit gravity sedimentation into four populations (designated regions I-IV) based on the prile cell distribution the resulting content radioimmunoassayable (RIA) hormones. The cells in regions II IV released thyrotropin (TSH) in response to thyrotropin-releasing hormone (TRW, 5 rig/ml); however, those in region Wreleased only -5% their RIA content, whereas those in region II released -26% in response to the same stimulus. Concomitant elevation CAMP cGMP occurred in region I.. cells but only cGMP was elevated in region IV cells. Mammotrophs were localized in region III- They responded to by releasing prolactin (PRL) exhibiting increased CAMP content. These data provide support for the existence two functionally distinct populations thyrotrophs in l&day-old female rats, The data also imply that CAMP is involved in -induced PRL release, whereas cGMP is involved in induced TSH release. cyclic nucleotides; separated thyrotropin; prolactin enriched cell populations; HORMONE () stimulates pituitary thyrotropin (TSH) prolactin (PRL) release (13, 17). Our previous studies suggested that http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Action of thyrotropin-releasing hormone on mammotrophs and thyrotrophs

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Publisher
The American Physiological Society
Copyright
Copyright © 1981 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
Publisher site
See Article on Publisher Site

Abstract

C. P. S. M. University Texas Health Science Center, Dallas, Texas 75235 G. 2. C. P. S. M. . thyrotropin-releasing hormone on mammotrophs thyrotrophs. Am. J. Physiol. 241 (Endocrinol. Metab. 4): E298-E304, 1981.-Anterior pituitary cells from 15-day-old female rats were separated by unit gravity sedimentation into four populations (designated regions I-IV) based on the prile cell distribution the resulting content radioimmunoassayable (RIA) hormones. The cells in regions II IV released thyrotropin (TSH) in response to thyrotropin-releasing hormone (TRW, 5 rig/ml); however, those in region Wreleased only -5% their RIA content, whereas those in region II released -26% in response to the same stimulus. Concomitant elevation CAMP cGMP occurred in region I.. cells but only cGMP was elevated in region IV cells. Mammotrophs were localized in region III- They responded to by releasing prolactin (PRL) exhibiting increased CAMP content. These data provide support for the existence two functionally distinct populations thyrotrophs in l&day-old female rats, The data also imply that CAMP is involved in -induced PRL release, whereas cGMP is involved in induced TSH release. cyclic nucleotides; separated thyrotropin; prolactin enriched cell populations; HORMONE () stimulates pituitary thyrotropin (TSH) prolactin (PRL) release (13, 17). Our previous studies suggested that

Journal

AJP - Endocrinology and MetabolismThe American Physiological Society

Published: Oct 1, 1981

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