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ACETYLCHOLINE LEVEL OF RAT CEREBRAL CORTEX UNDER CONDITIONS OF ANOXIA AND HYPOGLYCEMIA

ACETYLCHOLINE LEVEL OF RAT CEREBRAL CORTEX UNDER CONDITIONS OF ANOXIA AND HYPOGLYCEMIA ANOXIA Biological (Received UNDER AND H. CONDITIONS HYPOGLYCEMIA WELSH* OF Laboratories, Harvard University, -f Cambridge, Massachusetts for publication February 15, 1943) THE IMPORTANCE of oxygen and glucose in the synthesis of acetylcholine (ACh) by brain slices has been demonstrated by Quastel, Tennenbaum and Wheatley (15) and by Mann, Tennenbaum and Quastel (11, 12). The in uiuo synthesis of ACh by the superior cervical ganglion of the cat has also been shown to depend on an adequate supply of oxygen and glucose (7). However, attempts to demonstrate a change in the ACh level of the brain as a result of anoxia or hypoglycemia have thus far failed (9, 3). The present paper is an account of experiments which demonstrate, with reasonable certainty, that low atmospheric pressure (probably acting through anoxia), and insulin hypoglycemia, cause a decrease in the level of ACh in the of the rat. METHODS Rats of the Sprague-Dawley albino strain were used. These ranged in weight from 110 to 300 g. but the majority weighed between 200 and 250 g. Anoxia was produced by subjecting rats to low atmospheric pressure. The chamber was evacuated in steps of 50 or 100 mm. Hg with pauses of 10 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurophysiology The American Physiological Society

ACETYLCHOLINE LEVEL OF RAT CEREBRAL CORTEX UNDER CONDITIONS OF ANOXIA AND HYPOGLYCEMIA

John H. Welsh
Journal of Neurophysiology , Volume 6: 329 – Sep 1, 1943
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Publisher
The American Physiological Society
Copyright
Copyright © 1943 the American Physiological Society
ISSN
0022-3077
eISSN
1522-1598
Publisher site
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Abstract

ANOXIA Biological (Received UNDER AND H. CONDITIONS HYPOGLYCEMIA WELSH* OF Laboratories, Harvard University, -f Cambridge, Massachusetts for publication February 15, 1943) THE IMPORTANCE of oxygen and glucose in the synthesis of acetylcholine (ACh) by brain slices has been demonstrated by Quastel, Tennenbaum and Wheatley (15) and by Mann, Tennenbaum and Quastel (11, 12). The in uiuo synthesis of ACh by the superior cervical ganglion of the cat has also been shown to depend on an adequate supply of oxygen and glucose (7). However, attempts to demonstrate a change in the ACh level of the brain as a result of anoxia or hypoglycemia have thus far failed (9, 3). The present paper is an account of experiments which demonstrate, with reasonable certainty, that low atmospheric pressure (probably acting through anoxia), and insulin hypoglycemia, cause a decrease in the level of ACh in the of the rat. METHODS Rats of the Sprague-Dawley albino strain were used. These ranged in weight from 110 to 300 g. but the majority weighed between 200 and 250 g. Anoxia was produced by subjecting rats to low atmospheric pressure. The chamber was evacuated in steps of 50 or 100 mm. Hg with pauses of 10

Journal

Journal of Neurophysiology – The American Physiological Society

Published: Sep 1, 1943

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