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A study of regional distribution of renal blood flow using quantitative autoradiography

A study of regional distribution of renal blood flow using quantitative autoradiography N. WILLIAMS, MATERIALS AND METHODS iodoantipyrine; renal cortex; renal medulla; kidney THERE IS GOOD EVIDENCE to suggest that alterations in intrarenal blood flow are present in a variety of disease states (2, 12). Established techniques for measuring renal blood flow are limited both by the resolution of the method and the number of s possible in each kidney. Clearance techniques and electromagnetic flowmetry, for example, give a single value only for renal blood flow. Micropuncture methods provide better resolution but are invasive and do not allow precise identification of the anatomic region being studied. The most widely used method presently available for measuring the regional distribution blood flow is the reference microsphere sample technique (8). The technique allows focal s to be performed but there is a conflict between the resolution of this technique and the number of microspheres necessary in each sample for statistical accuracy (13). It is also known that axial streaming of beads may influence the pattern of flow density, particularly with larger-sized microspheres (8) Quantitative autoradiography has been used previously to measure cerebral (11) and gastrointestinal blood flow (7). The technique is based on the [ 1251]iodoantipyrine uptake method originally described by Landau et http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Renal Physiology The American Physiological Society

A study of regional distribution of renal blood flow using quantitative autoradiography

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Publisher
The American Physiological Society
Copyright
Copyright © 1992 the American Physiological Society
ISSN
0363-6127
eISSN
1522-1466
Publisher site
See Article on Publisher Site

Abstract

N. WILLIAMS, MATERIALS AND METHODS iodoantipyrine; renal cortex; renal medulla; kidney THERE IS GOOD EVIDENCE to suggest that alterations in intrarenal blood flow are present in a variety of disease states (2, 12). Established techniques for measuring renal blood flow are limited both by the resolution of the method and the number of s possible in each kidney. Clearance techniques and electromagnetic flowmetry, for example, give a single value only for renal blood flow. Micropuncture methods provide better resolution but are invasive and do not allow precise identification of the anatomic region being studied. The most widely used method presently available for measuring the regional distribution blood flow is the reference microsphere sample technique (8). The technique allows focal s to be performed but there is a conflict between the resolution of this technique and the number of microspheres necessary in each sample for statistical accuracy (13). It is also known that axial streaming of beads may influence the pattern of flow density, particularly with larger-sized microspheres (8) Quantitative autoradiography has been used previously to measure cerebral (11) and gastrointestinal blood flow (7). The technique is based on the [ 1251]iodoantipyrine uptake method originally described by Landau et

Journal

AJP - Renal PhysiologyThe American Physiological Society

Published: Nov 1, 1992

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