Abstract Right ventricular (RV) function is a powerful prognostic indicator in many forms of heart disease, but its assessment remains challenging and inexact. RV dysfunction may alter the normal patterns of RV blood flow, but those patterns have been incompletely characterized. We hypothesized that, based on anatomic differences, the proportions and energetics of RV flow components would differ from those identified in the left ventricle (LV) and that the portion of the RV inflow passing directly to outflow ( Direct Flow ) would be prepared for effective systolic ejection as a result of preserved kinetic energy (KE) compared with other RV flow components. Three-dimensional, time-resolved phase-contrast velocity, and balanced steady-state free-precession morphological data were acquired in 10 healthy subjects using MRI. A previously validated method was used to separate the RV and LV end-diastolic volumes into four flow components and measure their volume and KE over the cardiac cycle. The RV Direct Flow: 1 ) followed a smoothly curving route that did not extend into the apical region of the ventricle; 2 ) had a larger volume and possessed a larger presystolic KE (0.4 ± 0.3 mJ) than the other flow components ( P < 0.001 and P < 0.01, respectively); and 3 ) represented a larger part of the end-diastolic blood volume compared with the LV Direct Flow ( P < 0.01). These findings suggest that diastolic flow patterns distinct to the normal RV create favorable conditions for ensuing systolic ejection of the Direct Flow component. These flow-specific aspects of RV diastolic-systolic coupling provide novel perspectives on RV physiology and may add to the understanding of RV pathophysiology. cardiac disease interventricular function kinetic energy phase-contrast magnetic resonance imaging pump physiology Copyright © 2011 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print September 2011 , doi: 10.​1152/​ajpheart.​00622.​2011 AJP - Heart December 2011 vol. 301 no. 6 H2344-H2350 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: ajpheart.00622.2011v1 301/6/H2344 most recent Classifications Muscle Mechanics and Ventricular Function Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Fredriksson, A. G. Articles by Carlhäll, C. PubMed PubMed citation Articles by Fredriksson, A. G. Articles by Carlhäll, C. Related Content Muscle Mechanics and Ventricular Function Load related web page information Current Issue December 2011, 301 (6) Alert me to new issues of AJP - Heart About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2011 the American Physiological Society Print ISSN: 0363-6135 Online ISSN: 1522-1539 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview();

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