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W. Boston, G. Bleck, J. Conroy, M. Wheeler, D. Miller (2001)
Short communication: effects of increased expression of alpha-lactalbumin in transgenic mice on milk yield and pup growth.Journal of dairy science, 84 3
S. Lien, L. Gomez-Raya, T. Steine, E. Fimland, S. Rogne (1995)
Associations between casein haplotypes and milk yield traits.Journal of dairy science, 78 9
G. Bleck, R. Bremel (1993)
Correlation of the alpha-lactalbumin (+15) polymorphism to milk production and milk composition of Holsteins.Journal of dairy science, 76 8
(2001)
Effects of increased expression of alpha-lactalbumin in transgenic mice on milk yield and pup growth, 84
R. Renaville, N. Gengler, E. Vrech, A. Prandi, S. Massart, C. Corradini, C. Bertozzi, F. Mortiaux, A. Burny, D. Portetelle (1997)
Pit-1 gene polymorphism, milk yield, and conformation traits for Italian Holstein-Friesian bulls.Journal of dairy science, 80 12
G. Voelker, G. Bleck, M. Wheeler (1997)
Single-Base Polymorphisms Within the 5’ Flanking Region of the Bovine α-Lactalbumin GeneJournal of Dairy Science, 80
G. Bleck, Brett White, David Miller, Matthew Wheeler (1998)
Production of bovine alpha-lactalbumin in the milk of transgenic pigs.Journal of animal science, 76 12
G. Bleck, R. Bremel (1993)
Sequence and single-base polymorphisms of the bovine α-lactalbumin 5'-flanking regionGene, 126
A. Lunden, M. Lindersson (1998)
alpha-Lactalbumin polymorphism in relation to milk lactose.
The α-lactalbumin is a subunit of lactose-synthase, an enzyme responsible for lactose production, a disaccharide that influences milk production. Sequence variations of bovine α -lactalbumin have been associated with differences in milk yield. This study aimed to analyze allelic frequency differences at position − 1689 (g. A > G) and + 15 (g. A > G) of the α-lactalbumin gene in Holstein (Bos taurus) and Nellore (Bos indicus) cows. Blood samples were analyzed from 34 Holstein, 104 Nellore, and 99 Dairy Nellore cows using PCR-RFLP. The different RFLP patterns were sequenced and a novel sequence variation on nucleotide − 46 was identified. An adenine at this position was designated as the A allele and a guanine was designated B allele. The frequencies of alleles A − 1689, A − 46, and A + 15 differed between Holstein and both Nellore breeds. The results show that differences in α-lactalbumin allelic variants in the 5′-flanking and the 5′-UTR region might be associated with differences in milk production between Holstein cows and cows from Nellore breeds. However, the lack of difference between Nellore and Dairy Nellore suggests that other sequence variantions that regulate milk production might be responsible for the selection of Dairy Nellore cows with superior milk production.
Animal Biotechnology – Taylor & Francis
Published: Jul 7, 2008
Keywords: Bovine; Holstein; α -Lactalbumin; Nellore; Sequence variation
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