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ENHANCEMENT OF DNA HYBRIDIZATION KINETICS IN MICROARRAYS BY CONVECTIVE TRANSPORT

Chemical Engineering Communications , Volume 195 (2): 167-186 – Feb 1, 2008

Details

Publisher
Taylor & Francis
Copyright
© 2008 Informa plc
Subject
DNA hybridization
ISSN
0098-6445
D.O.I.
10.1080/00986440701569283
Publisher site
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ENHANCEMENT OF DNA HYBRIDIZATION KINETICS IN MICROARRAYS BY CONVECTIVE TRANSPORT

Abstract

We use the finite element method (Comsol Multiphysics software) to study the kinetics of DNA hybridization and the potential limitation of the reaction rate caused by diffusion effects. The value of the parameters influencing the kinetics can sometimes span several orders of magnitude. Therefore, a wide range of values was used in order to cover the conditions seen in DNA microarrays. In the cases where hybridization is diffusion limited, a convective transport is added to successfully overcome this limitation.
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