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M. Siperstein, R. Unger, L. Madison (1968)
Studies of muscle capillary basement membranes in normal subjects, diabetic, and prediabetic patients.The Journal of clinical investigation, 47 9
A. Gonet, W. Stauffacher, R. Pictet, A. Renold (1966)
Obesity and diabetes mellitus with striking congenital hyperplasia of the islets of langerhans in spiny mice (Acomys Cahirinus)Diabetologia, 1
M. Salas, E. Viñuela, A. Sols (1963)
INSULIN-DEPENDENT SYNTHESIS OF LIVER GLUCOKINASE IN THE RAT.The Journal of biological chemistry, 238
J. Bloodworth, R. Engerman, K. Powers (1969)
Experimental Diabetic Microangiopathy: 1. Basement Membrane Statistics in the DogDiabetes, 18
D. Coleman, K. Hummel (1967)
Studies with the mutation, diabetes, in the mouseDiabetologia, 3
I. Seidman, A. Horland, G. Teebor (1967)
Hepatic glycolytic and gluconeogenic enzymes of the obese-hyperglycemic mouse.Biochimica et biophysica acta, 146 2
F. Hefti, E. Flückiger (1967)
Obesitas und diabetes-mellitus bei Acomys cahirinusRevue Suisse De Zoologie, 74
George Weber, R. Singhal, S. Srivastava (1965)
INSULIN: SUPPRESSOR OF BIOSYNTHESIS OF HEPATIC GLUCONEOGENIC ENZYMES.Proceedings of the National Academy of Sciences of the United States of America, 53
J. Williamson, N. Vogler, C. Kilo (1969)
Estimation of Vascular Basement Membrane Thickness: Theoretical and Practical ConsiderationsDiabetes, 18
125 6 6 3 3 W. Creutzfeldt D. Mende B. Willms H. D. Söling Department of Medicine University of Goettingen W.Germany Summary Vascular basement membrane thickness in the muscle was measured in spiny mice according to the method of Siperstein et al . (1968). The mean basement membrane width in spiny mice with normal glucose tolerance was 73±16 nm and in spiny mice with moderately and severely impaired glucose tolerance 75±18 and 80±18 nm respectively. In spiny mice with long lasting overt ketotic diabetes the basement membrane width was 105±9 nm. This small increase is unlikely to be related to diabetes since it is within the range of basement membrane thickness measured in normal swiss mice and far below the range described in human and experimental diabetes. — The activity of different enzymes of glycolysis and gluconeogenesis was measured in the liver of animals with experimental and spontaneous diabetes and in untreated human diabetes. The pattern of liver enzyme activity found under the different conditions could be related to the type of diabetes present. In the case of insulin deficiency (acute streptozotocin diabetes of rats, ketotic type of diabetes of spiny mice and untreated human juvenile diabetes) there is a decrease in the activity of GK, PFK and PK while FDPase and G-6-Pase activity was increased and aldolase activity unchanged. In the case of non-ketotic diabetes (mild spontaneous diabetes of spiny mice, obese hyperglycemic Bar Harbor mice, New Zealand obese mice, human maturity onset type diabetes) the activity of glucokinase was significantly increased. While the activity of gluconeogenetic enzymes increased only in the more severe states of hyperglycemia, the activity of PK increased only in the milder forms of the non-ketotik diabetes.
Diabetologia – Springer Journals
Published: Jun 1, 1970
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