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Time-dependent exacerbation of amphetamine-induced taste aversions following exposure to footshock

Time-dependent exacerbation of amphetamine-induced taste aversions following exposure to footshock 213 125 125 1 1 W. J. Bowers Z. Amit M. A. Gringras Centre for Studies in Behavioral Neurobiology, Dept. Psychology Concordia University 1455 de Maisonneuve Blvd. West H3G 1M8 Montreal Quebec Canada Department of Psychoneuropharmacologie Catholic University of Nijmegen P.O. Box 9101 6500 HB Nijmegen The Netherlands Abstract Previous studies have shown that stressors attenuate LiCl-induced conditioned taste aversions (CTA) but not morphine-induced CTA. The current studies examined the effects of footshock on the acquisition and extinction of amphetamine-induced CTA. Experiment 1 demonstrated that exposure to 30 footshocks between saccharin consumption and amphetamine injections did not alter either the acquisition or the extinction of amphetamine-CTA. Experiment 2 demonstrated that exposure to the same shock parameters 2 and 4 days before saccharin-amphetamine pairing increased the magnitude of amphetamine-CTA after one saccharin-amphetamine pairing and delayed the recovery from the CTA. Experiment 2 also demonstrated that footshock increased the initial neophobic response to novel saccharin but did not alter subsequent saccharin consumption among saline-injected animals. These results indicate that stress-induced facilitation of amphetamine CTA are time-dependent and contrast with reports that stressors attenuate LiCl CTA. They also add support to the contention that CTAs induced by self-administered drugs like amphetamine are qualitatively different from CTAs induced by toxic substances like LiCL. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Time-dependent exacerbation of amphetamine-induced taste aversions following exposure to footshock

Psychopharmacology , Volume 125 (1) – May 1, 1996

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References (36)

Publisher
Springer Journals
Copyright
Copyright © 1996 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF02247391
Publisher site
See Article on Publisher Site

Abstract

213 125 125 1 1 W. J. Bowers Z. Amit M. A. Gringras Centre for Studies in Behavioral Neurobiology, Dept. Psychology Concordia University 1455 de Maisonneuve Blvd. West H3G 1M8 Montreal Quebec Canada Department of Psychoneuropharmacologie Catholic University of Nijmegen P.O. Box 9101 6500 HB Nijmegen The Netherlands Abstract Previous studies have shown that stressors attenuate LiCl-induced conditioned taste aversions (CTA) but not morphine-induced CTA. The current studies examined the effects of footshock on the acquisition and extinction of amphetamine-induced CTA. Experiment 1 demonstrated that exposure to 30 footshocks between saccharin consumption and amphetamine injections did not alter either the acquisition or the extinction of amphetamine-CTA. Experiment 2 demonstrated that exposure to the same shock parameters 2 and 4 days before saccharin-amphetamine pairing increased the magnitude of amphetamine-CTA after one saccharin-amphetamine pairing and delayed the recovery from the CTA. Experiment 2 also demonstrated that footshock increased the initial neophobic response to novel saccharin but did not alter subsequent saccharin consumption among saline-injected animals. These results indicate that stress-induced facilitation of amphetamine CTA are time-dependent and contrast with reports that stressors attenuate LiCl CTA. They also add support to the contention that CTAs induced by self-administered drugs like amphetamine are qualitatively different from CTAs induced by toxic substances like LiCL.

Journal

PsychopharmacologySpringer Journals

Published: May 1, 1996

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