F. Denis E. Rhéaume S. M. Aouad A. Alam R.-P. Sékaly L. Y. Cohen Laboratoire d'Immunologie, Institut de Recherches Cliniques de Montréal, 110, Av. des Pins Ouest, Montréal (QC), H2W 1R7 (Canada), Fax +1 514 987 5711, e-mail: Sekalyr@IRCM.UMontreal.CA CA Département de Microbiologie-Immunologie, Faculté de Médecine, Université de Montréal, Montréal (QC), H3C 3J7 (Canada) CA Department of Microbiology and Immunology, School of Medicine, McGill University, Montréal (QC), H3A 2B4 (Canada) CA Abstract. Apoptosis is responsible for the removal of potentially autoreactive or useless T cells during thymic selection and activated T cells in the periphery. Specific families of receptors, kinases, transcription factors, and cysteine proteases, termed caspases, are involved in the apoptotic cascade leading to proteolysis of specific substrates and to morphological changes associated with programmed cell death. Although common members of the apoptotic cascade are shared between different cell types, it appears that cell-specific factors can influence the response to a given apoptotic stimuli. Characterization and understanding of the basic mechanisms involved in the different pathways protecting or leading to cell death may provide novel ways to control inappropriate apoptosis involved in several diseases.
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The role of caspases in T cell development and the control of immune responses
F., Denis; E., Rhéaume; S. M., Aouad; A., Alam; R.-P., Sékaly; L. Y., Cohen
Follow Cellular and Molecular Life Sciences
, Volume 54 (9)
Springer Journals – Sep 1, 1998
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