Access the full text.
Sign up today, get DeepDyve free for 14 days.
JC Henquin (1981)
E245Am J Physiol, 240
J. Henquin, A. Lambert (1975)
Cobalt inhibition of insulin secretion and calcium uptake by isolated rat islets.The American journal of physiology, 228 6
W. Ward, D. Bolgiano, B. McKnight, J. Halter, D. Porte (1984)
Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus.The Journal of clinical investigation, 74 4
J. Henquin, H. Meissner (1984)
Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic B-cellsExperientia, 40
B. Hellman, J. Sehlin, I. Täljedal (1971)
Effects of glucose and other modifiers of insulin release on the oxidative metabolism of amino acids in micro-dissected pancreatic islets.The Biochemical journal, 123 4
Meissner Hp (1976)
Electrical characteristics of the beta-cells in pancreatic islets.Journal de physiologie, 72
I. Atwater, C. Dawson, G. Eddlestone, E. Rojas (1981)
Voltage noise measurements across the pancreatic beta‐cell membrane: calcium channel characteristics.The Journal of Physiology, 314
S. Charles, T. Tamagawa, J. Henquin (1982)
A single mechanism for the stimulation of insulin release and 86Rb+ efflux from rat islets by cationic amino acids.The Biochemical journal, 208 2
J. Gerich, M. Charles, G. Grodsky (1974)
Characterization of the effects of arginine and glucose on glucagon and insulin release from the perfused rat pancreas.The Journal of clinical investigation, 54 4
B. Hellman, J. Sehlin, I. Täljedal (1971)
Uptake of Alanine, Arginine, and Leucine by Mammalian Pancreatic β-CellsEndocrinology, 89
J. Palmer, J. Benson, R. Walter, J. Ensinck (1976)
Arginine-stimulated acute phase of insulin and glucagon secretion in diabetic subjects.The Journal of clinical investigation, 58 3
S. Levin, J. Karam, S. Hane, G. Grodsky, P. Forsham (1971)
Enhancement of Arginine-induced Insulin Secretion in Man by Prior Administration of GlucoseDiabetes, 20
F. Ashcroft, S. Ashcroft, D. Harrison (1987)
Effects of 2‐ketoisocaproate on insulin release and single potassium channel activity in dispersed rat pancreatic beta‐cells.The Journal of Physiology, 385
S. Charles, Jean-Claude HENQUINt (1983)
Distinct effects of various amino acids on 45Ca2+ fluxes in rat pancreatic islets.The Biochemical journal, 214 3
J. Henquin (1980)
Tolbutamide stimulation and inhibition of insulin release: Studies of the underlying ionic mechanisms in isolated rat isletsDiabetologia, 18
G. Trube, P. Rorsman, T. Ohno-Shosaku (1986)
Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic β-cellsPflügers Archiv, 407
A. Pagliara, S. Stillings, B. Hover, D. Martin, F. Matschinsky (1974)
Glucose modulation of amino acid-induced glucagon and insulin release in the isolated perfused rat pancreas.The Journal of clinical investigation, 54 4
J. Henquin, S. Charles, M. Nenquin, F. Mathot, T. Tamagawa (1982)
Diazoxide and D600 Inhibition of Insulin Release: Distinct Mechanisms Explain the Specificity for Different StimuliDiabetes, 31
A. Widström, E. Cerasi (1973)
On the action of tolbutamide in normal man. 3. Interaction of tolbutamide with glucagon, aminophylline and arginine in stimulating insulin response.Acta endocrinologica, 72 3
S. Levin, G. Grodsky, R. Hagura, D. Smith, P. Forsham (1972)
Relationships between arginine and glucose in the induction of insulin secretion from the isolated, perfused rat pancreas.Endocrinology, 90 3
J. Floyd, S. Fajans, S. Pek, C. Thiffault, R. Knopf, J. Conn (1970)
Synergistic Effect of Essential Amino Acids and Glucose upon Insulin Secretion in ManDiabetes, 19
A. Widström, E. Cerasi (1973)
On the action of tolbutamide in normal man. I. Role of adrenergic mechanisms in tolbutamide-induced insulin release during normoglycaemia and induced hypoglycaemia.Acta endocrinologica, 72 3
S. Efendić, E. Cerasi, R. Luft (1971)
Role of glucose in arginine-induced insulin release in man.Metabolism: clinical and experimental, 20 6
J. Henquin, H. Meissner (1982)
Opposite effects of tolbutamide and diazoxide on 86Rb+ fluxes and membrane potential in pancreatic B cells.Biochemical pharmacology, 31 7
P. Hollander, C. Asplin, J. Palmer (1982)
Glucose Modulation of Insulin and Glucagon Secretion in Nondiabetic and Diabetic ManDiabetes, 31
G. Dimitriadis, G. Pehling, J. Gerich (1985)
Abnormal Glucose Modulation of Islet A- and B-Cell Responses to Arginine in Non-insulin-dependent Diabetes MellitusDiabetes, 34
EK Matthews (1985)
93
A. Herchuelz, P. Lebrun, A. Boschero, W. Malaisse (1984)
Mechanism of arginine-stimulated Ca2+ influx into pancreatic B cell.The American journal of physiology, 246 1 Pt 1
A Herchuelz (1984)
E38Am J Physiol, 246
J. Henquin, H. Meissner (1981)
Effects of amino acids on membrane potential and 86Rb+ fluxes in pancreatic beta-cells.The American journal of physiology, 240 3
J. Henquin (1979)
Opposite effects of intracellular Ca2+ and glucose on K+ permeability of pancreatic islet cellsNature, 280
J. Palmer, R. Walter, J. Ensinck (1975)
Arginine-stimulated Acute Phase of Insulin and Glucagon Secretion: I. In Normal ManDiabetes, 24
S. Ashcroft, C. Hedeskov, P. Randle (1970)
Glucose metabolism in mouse pancreatic islets.The Biochemical journal, 118 1
U. Panten, J. Christians (2004)
Effects of 2-endo-aminonorbornane-2-carboxylic acid upon insulin secretion and fluorescence of reduced pyridine nucleotides of isolated perifused pancreatic isletsNaunyn-Schmiedeberg's Archives of Pharmacology, 276
M. MacDonald, H. Ammon, T. Patel, J. Steinke (1974)
Failure of 6-aminonicotinamide to inhibit the potentiating effect of leucine and arginine on glucose-induced insulin release in vitroDiabetologia, 10
HP Meissner (1976)
757J Physiol (Paris), 72
H. Meissner, H. Schmelz (2004)
Membrane potential of beta-cells in pancreatic isletsPflügers Archiv, 351
M. Pfeifer, J. Halter, R. Graf, D. Porte (1980)
Potentiation of Insulin Secretion to Nonglucose Stimuli in Normal Man by TolbutamideDiabetes, 29
J. Iversen (1971)
Secretion of glucagon from the isolated, perfused canine pancreas.The Journal of clinical investigation, 50 10
125 30 30 8 8 M. P. Hermans W. Schmeer J. C. Henquin Unité de Diabétologie et Nutrition University of Louvain, Faculty of Medicine Brussels Belgium I Physiologisches Institut, University of Saarland Homburg/Saar FRG Summary Mouse islets were used to study how glucose modulates arginine stimulation of insulin release. At 3 mmol/l glucose, arginine (20 mmol/l) decreased the resting membrane potential of B cells by about 10 mV, but did not evoke electrical activity. This depolarisation was accompanied by a slight but rapid acceleration of 86 Rb + efflux and 45 Ca 2+ influx. However, 45 Ca 2+ efflux and insulin release increased only weakly and belatedly. When the membrane was depolarised by threshold (7 mmol/l) or stimulatory (10–15 mmol/l) concentrations of glucose, arginine rapidly induced or augmented electrical activity, markedly accelerated 86 Rb + efflux, 45 Ca 2+ influx and efflux, and triggered a strong and fast increase in insulin release. When glucose-induced depolarisation of the B-cell membrane was prevented by diazoxide, arginine lost all effects but those produced at low glucose. However, the delayed increase in release still exhibited some glucose-dependency. In contrast, depolarisation by tolbut amide, at low glucose, largely mimicked the permissive effect of high glucose. Depolarisation by high K + also amplified arginine stimulation of insulin release, but did not accelerate it as did glucose or tolbutamide. Omission of extracellular Ca 2+ abolished the releasing effect of arginine under all conditions. The results thus show that the permissive action of glucose mainly results from its ability to depolarise the B-cell membrane. It enables the small depolarisation by arginine itself to activate Ca channels more rapidly and efficiently. Changes in the metabolic state of B cells may also contribute to this permissive action by increasing the efficacy of the initiating signal triggered by arginine.
Diabetologia – Springer Journals
Published: Aug 1, 1987
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.