Bacillus subtilis is an effective probiotic product for prevention of enteric infections both in humans and animals. We hypothesized that a mouth rinse containing Bacillus subtilis should adhere to and colonize part of the oral bacteria on periodontal tissue. The rinsing ability of Extraction 300E (containing Bacillus subtilis: E-300 ) was compared with that of a mouth wash liquid , Neosteline Green (benzethonium chloride; NG) that is commonly used in Japan. Compared with NG rinsing, E-300 rinsing resulted in a marked change in the BANA-score. The mean BANA values (score ± SD) over the course of the study from 0 to 30 days were 1.52 ± 0.51 ( p ≤ 0.1) and 0.30 ± 0.47 ( p ≤ 0.01) for E-300, and 1.56 ± 0.51 and 0.93 ± 0.68 for NG, respectively. Gingival Index also had improvement, while probing pocket depth and bleeding on probing showed small improvements. Mouth rinsing with E-300 significantly reduced periodontal pathogens compared with NG. These results suggest that Bacillus subtilis is an appropriate mouth rinse for patients with periodontitis.
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The effect of Bacillus subtilis mouth rinsing in patients with periodontitis
S., Tsubura; H., Mizunuma; S., Ishikawa; I., Oyake; M., Okabayashi; K., Katoh; M., Shibata; T., Iizuka; T., Toda; T., Iizuka
Follow European Journal of Clinical Microbiology Infectious Diseases
, Volume 28 (11)
Springer Journals – Nov 1, 2009
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