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- Publisher
- Springer Journals
- Copyright
- Copyright © 1974 by Springer-Verlag
- Subject
- Biomedicine; Pharmacology/Toxicology
- ISSN
- 0031-6970
- eISSN
- 1432-1041
- DOI
- 10.1007/BF00558214
- Publisher site
- See Article on Publisher Site
Abstract
228 7 7 5 5 K. K. Adjepon-Yamoah D. B. Scott L. F. Prescott University Departments of Therapeutics and Anaesthetics The Royal Infirmary Edinburgh Scotland Summary The effect of intramuscular atropine (0.6 mg) on the absorption of orally administered lidocaine (400 mg) was investigated in four healthy volunteers and in 12 laparoscopy patients. The time taken to achieve peak plasma lidocaine concentration was significantly delayed when lidocaine and atropine were given at the same time. The mean individual peak plasma lidocaine concentrations were reduced by atropine but the differences were not statistically significant. Anaesthesia and laparoscopy caused a further inhibition of lidocaine absorption. Atropine probably delayed the absorption of lidocaine by inhibition of gastric emptying.
Journal
European Journal of Clinical Pharmacology – Springer Journals
Published: Sep 1, 1974