A. Salminen +358 17162048 antero.salminen@uku.fi M. Lehtonen T. Suuronen K. Kaarniranta J. Huuskonen Department of Neurology, Institute of Clinical Medicine University of Kuopio P.O. Box 1627 Kuopio 70211 Finland Department of Neurology Kuopio University Hospital P.O. Box 1777 70211 Kuopio Finland Department of Pharmaceutical Chemistry University of Kuopio P.O. Box 1627 70211 Kuopio Finland Department of Ophthalmology, Institute of Clinical Medicine University of Kuopio P.O. Box 1627 70211 Kuopio Finland Department of Ophthalmology Kuopio University Hospital P.O. Box 1777 70211 Kuopio Finland Abstract. Traditional medicine has been a fertile source for revealing novel lead molecules for modern drug discovery. In plants, terpenoids represent a chemical defense against environmental stress and provide a repair mechanism for wounds and injuries. Interestingly, effective ingredients in several plant-derived medicinal extracts are also terpenoid compounds of monoterpenoid, sesquiterpenoid, diterpenoid, triterpenoid and carotenoid groups. Inflammatory diseases and cancer are typical therapeutic indications of traditional medicines. Thus folk medicine supports the studies which have demonstrated that plant-derived terpenoid ingredients can suppress nuclear factor-κB (NF-κB) signaling, the major regulator in the pathogenesis of inflammatory diseases and cancer.We review the extensive literature on the different types of terpenoid molecules, totalling 43, which have been verified both inhibiting the NF-κB signaling and suppressing the process of inflammation and cancer. It seems that during evolution, plants have established a terpene-based host defense which also represents a cornucopia of effective therapeutic compounds for common human diseases.
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Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential
A., Salminen; M., Lehtonen; T., Suuronen; K., Kaarniranta; J., Huuskonen
Follow Cellular and Molecular Life Sciences
, Volume 65 (19)
Springer Journals – Oct 1, 2008
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