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Synthesis of cytotoxic derivatives of 2-oxo-1-azetidinylacetamide

Synthesis of cytotoxic derivatives of 2-oxo-1-azetidinylacetamide New derivatives of 2-oxo-1-azetidinylacetamide have been synthesized by the four-component condensation of β-amino acids with aldehydes and isonitriles. Study of their cytotoxic activity in vitro revealed a cytotoxic effect of individual compounds in relation to cancer cells of human fibrosarcoma, mouse hepatoma, and mouse neuroblastoma. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemistry of Heterocyclic Compounds Springer Journals

Synthesis of cytotoxic derivatives of 2-oxo-1-azetidinylacetamide

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References (6)

Publisher
Springer Journals
Copyright
Copyright © 2005 by Springer Science+Business Media, Inc.
Subject
Chemistry; Organic Chemistry; Pharmacy
ISSN
0009-3122
eISSN
1573-8353
DOI
10.1007/s10593-005-0113-8
Publisher site
See Article on Publisher Site

Abstract

New derivatives of 2-oxo-1-azetidinylacetamide have been synthesized by the four-component condensation of β-amino acids with aldehydes and isonitriles. Study of their cytotoxic activity in vitro revealed a cytotoxic effect of individual compounds in relation to cancer cells of human fibrosarcoma, mouse hepatoma, and mouse neuroblastoma.

Journal

Chemistry of Heterocyclic CompoundsSpringer Journals

Published: Apr 30, 2005

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