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New derivatives of 2-oxo-1-azetidinylacetamide have been synthesized by the four-component condensation of β-amino acids with aldehydes and isonitriles. Study of their cytotoxic activity in vitro revealed a cytotoxic effect of individual compounds in relation to cancer cells of human fibrosarcoma, mouse hepatoma, and mouse neuroblastoma.
Chemistry of Heterocyclic Compounds – Springer Journals
Published: Apr 30, 2005
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