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Pharmaceutical Chemistry Journal Vol. 35, No. 2, 2001 SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF NEW 3-ARYL-1-(8-BROMO-3,4-DIHYDRO-2H-1,5-BENZODIOXEPIN-7-YL)- 2-PROPEN-1-ONES 1 1 1 1 1 L. K. Labanauskas, A. B. Brukðtus, P. G. Gaidelis, E. B. Udrenaite, V. A. Buchinskaite, 1 1 M. M. Mitskus, and V. K. Daukðas Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 35, No. 2, pp. 9 – 10, February, 2001. Original article submitted October 5, 1990. Recently [1], compounds combining antiinflammatory EXPERIMENTAL CHEMICAL PART activity and low toxicity were found among 2-bromine-sub- stituted derivatives of 5,6-dialkoxybenzophenone. It is The initial compound was commercial 7-acetyl-8-bro- known that the antiinflammatory activity is also inherent in mo-3,4-dihydro-2H-1,5-benzodioxepine (Maybridge Chemi- 3,4-dialkoxychalcones [2, 3] and that the activity of 3,4-dial- cal Co. Ltd. koxybenzophenones and 3,4-dialkoxychalcones (their vi- The IR absorption spectra were measured with a Spec- nylogs) exhibit a similar character [3, 4]. In this context, it trum BX FT-IR Fourier-transform IR spectrometer (Sweden) was of interest to synthesize and characterize a series of new using samples prepared as nujol mulls. The UV spectra were 3-aryl-1-(8-bromo-3,4-dihydro-2H-1,5-benzodioxepin-7-yl)- recorded on a Lambda 20 UV/VIS spectrophotometer (Swe- 2-propen-1-ones (Ia – Ii) with the formula den) using 95 % ethanol as a solvent. The H NMR spectra were
Pharmaceutical Chemistry Journal – Springer Journals
Published: Oct 9, 2004
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