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Some physiological functions of the L -leucine dehydrogenase in Bacillus subtilis

Some physiological functions of the L -leucine dehydrogenase in Bacillus subtilis 203 109 109 1 2 Norbert Obermeier Karl Poralla Lehrbereich Mikrobiologie I Institut für Biologie II der Universität Auf der Morgenstelle 28 D-7400 Tübingen 1 Germany Abstract Mutants of Bacillus subtilis constitutive for L -leucine dehydrogenase synthesis were selected. Using these mutants we could determine two functional roles for the L -leucine dehydrogenase. This enzyme liberates ammonium ions from branched chain amino acids when supplied as the sole nitrogen source. Another function is to synthesize from L -isoleucine, L -leucine, and L -valine the branched chain α-keto acids which are precursors of branched chain fatty acid biosynthesis. These results together with the inducibility of the enzyme suggest that the L -leucine dehydrogenase has primarily a catabolic rather than an anabolic function in the metabolism of Bacillus subtilis . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Microbiology Springer Journals

Some physiological functions of the L -leucine dehydrogenase in Bacillus subtilis

Obermeier, Norbert; Poralla, Karl
Archives of Microbiology , Volume 109 (1) – Aug 1, 1976
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References (20)

Publisher
Springer Journals
Copyright
Copyright © 1976 by Springer-Verlag
Subject
Life Sciences; Biotechnology; Biochemistry, general; Cell Biology; Ecology; Microbial Ecology; Microbiology
ISSN
0302-8933
eISSN
1432-072X
DOI
10.1007/BF00425113
Publisher site
See Article on Publisher Site

Abstract

203 109 109 1 2 Norbert Obermeier Karl Poralla Lehrbereich Mikrobiologie I Institut für Biologie II der Universität Auf der Morgenstelle 28 D-7400 Tübingen 1 Germany Abstract Mutants of Bacillus subtilis constitutive for L -leucine dehydrogenase synthesis were selected. Using these mutants we could determine two functional roles for the L -leucine dehydrogenase. This enzyme liberates ammonium ions from branched chain amino acids when supplied as the sole nitrogen source. Another function is to synthesize from L -isoleucine, L -leucine, and L -valine the branched chain α-keto acids which are precursors of branched chain fatty acid biosynthesis. These results together with the inducibility of the enzyme suggest that the L -leucine dehydrogenase has primarily a catabolic rather than an anabolic function in the metabolism of Bacillus subtilis .

Journal

Archives of Microbiology – Springer Journals

Published: Aug 1, 1976

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