Society of General Internal Medicine 25th Annual Meeting Atlanta, Georgia May 2±4, 2002 ABSTRACTS Aggressive intravenous hydration was initiated resulting in preservation of renal function. The CPK peaked at 65,000 mg/dL before returning to normal. DISCUSSION: The brown recluse spider is endemic to the south and prefers to shelter in infrequently used or secluded areas. A history of exposure to secluded areas is therefore important in making the diagnosis. Although the majority of bites are limited to a local reaction, ten percent of the cases may result in a severe local reaction or systemic symptoms (Loxoscelism). Loxoscelism is characterized by fever, vomiting, myalgias and hemolysis. Anuria may develop; but acute renal failure is rare. Severe skin necrosis occurs in twenty percent and one percent develop extensive hemolysis. The spider bites are treated with local antibiotics and dapsone while only supportive care can be offered for the systemic manifestations. Persistence of general symptoms following a brown recluse spider bite should prompt consideration of rhabdomyolysis. CLINICAL VIGNETTES CYCLOSPORINE-INDUCED THROMBOTIC MICROANGIOPATHY IN A RENAL TRANSPLANT PATIENT. A. Abdel Latif1, H. Jneid1, I. Tleyjeh1, W. Braun1; 1Cleveland Clinic, Cleveland, OH (Tracking ID #52426) LEARNING OBJECTIVES: 1. Learn the differential diagnosis of renal
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