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Ann Hematol (2014) 93:1603–1604 DOI 10.1007/s00277-013-1993-9 LETTER TO THE EDITOR Smouldering systemic mastocytosis with lymph node involvement mimicking malignant lymphoma Z. Xu & B. Jamison & I. Bence-Bruckler Received: 15 November 2013 /Accepted: 5 December 2013 /Published online: 15 December 2013 Springer-Verlag Berlin Heidelberg 2013 Dear Editor, abnormal cells possessed a paratrabecular pattern, cuffing A 65-year-old male was referred for assessment of enlarged the bone trabecular (Fig. 1c). The abnormal cells accounted abdominal lymphadenopathy (Fig. 1a) detected by a CT/ for 30-40 % of bone marrow mononuclear cells, morpholog- abdomen 3 years ago. CT scan also demonstrated that the ically suggestive of mast cells. The abnormal cells were vertebral bodies and pelvic bones had diffusely heterogeneous positive for tryptase, CD25 (Fig. 1d, e), CD117, and CD68, appearance which might relate to sclerotic disease (Fig. 1b). A confirming that they were neoplastic mast cells. CD3 and repeated CT/abdomen confirmed a progressive lymphadenop- CD20 showed no lymphoma involvement in the bone mar- athy in the retroperitoneal and mesenteric region with spleno- row. According to WHO systemic mastocytosis (SM) diag- megaly and sclerotic bone lesions. Patient had no constitu- nostic criteria, it met the major criteria and two minor criteria. tional symptoms.
Annals of Hematology – Springer Journals
Published: Sep 1, 2014
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