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B. Sjöquist, E. Anggard (1972)
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Birgitta Sjöquist, Björn Lindström, Erik Änggård (1975)
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213 48 48 2 2 Carl-Gunnar Swahn Bengt Sandgärde Frits-Axel Wiesel Göran Sedvall Division of Neuropsychopharmacology, Department of Pharmacology Karolinska Institutet S-104 01 Stockholm Sweden Abstract A mass fragmentographic method for the simultaneous determination of 4-hydroxy-3-methoxyphenylacetic acid (HVA), 4-hydroxy-3-methoxyphenylethylene glycol (MOPEG), and 5-hydroxyindole-3-acetic acid (5-HIAA) was described. Deuterated analogues of the compounds were used as internal standards. The specificity was proved by multiple ion analysis. The experimental error was below 7% when applied to the analysis of human lumbar cerebrospinal fluid, urine, or rat brain tissue. In cerebrospinal fluid the major part of the monoamine metabolites occurred in the free form. In rat brain and human urine considerable amounts of conjugated HVA was found.
Psychopharmacology – Springer Journals
Published: Jan 1, 1976
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