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Simultaneous determination of the three major monoamine metabolites in brain tissue and body fluids by a mass fragmentographic method

Simultaneous determination of the three major monoamine metabolites in brain tissue and body... 213 48 48 2 2 Carl-Gunnar Swahn Bengt Sandgärde Frits-Axel Wiesel Göran Sedvall Division of Neuropsychopharmacology, Department of Pharmacology Karolinska Institutet S-104 01 Stockholm Sweden Abstract A mass fragmentographic method for the simultaneous determination of 4-hydroxy-3-methoxyphenylacetic acid (HVA), 4-hydroxy-3-methoxyphenylethylene glycol (MOPEG), and 5-hydroxyindole-3-acetic acid (5-HIAA) was described. Deuterated analogues of the compounds were used as internal standards. The specificity was proved by multiple ion analysis. The experimental error was below 7% when applied to the analysis of human lumbar cerebrospinal fluid, urine, or rat brain tissue. In cerebrospinal fluid the major part of the monoamine metabolites occurred in the free form. In rat brain and human urine considerable amounts of conjugated HVA was found. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Simultaneous determination of the three major monoamine metabolites in brain tissue and body fluids by a mass fragmentographic method

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References (17)

Publisher
Springer Journals
Copyright
Copyright © 1976 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00423253
Publisher site
See Article on Publisher Site

Abstract

213 48 48 2 2 Carl-Gunnar Swahn Bengt Sandgärde Frits-Axel Wiesel Göran Sedvall Division of Neuropsychopharmacology, Department of Pharmacology Karolinska Institutet S-104 01 Stockholm Sweden Abstract A mass fragmentographic method for the simultaneous determination of 4-hydroxy-3-methoxyphenylacetic acid (HVA), 4-hydroxy-3-methoxyphenylethylene glycol (MOPEG), and 5-hydroxyindole-3-acetic acid (5-HIAA) was described. Deuterated analogues of the compounds were used as internal standards. The specificity was proved by multiple ion analysis. The experimental error was below 7% when applied to the analysis of human lumbar cerebrospinal fluid, urine, or rat brain tissue. In cerebrospinal fluid the major part of the monoamine metabolites occurred in the free form. In rat brain and human urine considerable amounts of conjugated HVA was found.

Journal

PsychopharmacologySpringer Journals

Published: Jan 1, 1976

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