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Recovery time as a measure of CER strength: Effects of benzodiazepines, amobarbital, chlorpromazine and amphetamine

Recovery time as a measure of CER strength: Effects of benzodiazepines, amobarbital,... 213 12 12 1 1 S. S. Tenen Medical Research Laboratories Chas. Pfizer & Co., Inc. Groton Connecticut Summary and Conclusions A procedure was presented that used recovery time (the time the rat requires to resume drinking after the CS presentation) as a measure of CER strength. This measure varied directly with two of the more important conditioning variables: US (shock) intensity and number of training trials. Since the CS is imposed upon ongoing drinking behavior recovery time is also affected by thirst motivation. Several selected drugs were tested with this procedure. The anxietyreducing benzodiazepines (chlordiazepoxide, diazepam and nitrazepam) and amobarbital produced faster recovery times as compared with controls. In contrast, chlorpromazine produced a non-significant increase in recovery time. The stimulant, d-amphetamine, did not affect the recovery time measure in any significant way. The faster recovery times produced by chlordiazepoxide were shown not to be a result of a state-dependent (dissociated) learning effect or an increase in thirst motivation. It is believed that this simple procedure can be used to investigate drugs (or other variables) that might affect CER strength. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Recovery time as a measure of CER strength: Effects of benzodiazepines, amobarbital, chlorpromazine and amphetamine

Tenen, S.
Psychopharmacology , Volume 12 (1) – Jan 1, 1967
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References (30)

Publisher
Springer Journals
Copyright
Copyright © 1967 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00402749
Publisher site
See Article on Publisher Site

Abstract

213 12 12 1 1 S. S. Tenen Medical Research Laboratories Chas. Pfizer & Co., Inc. Groton Connecticut Summary and Conclusions A procedure was presented that used recovery time (the time the rat requires to resume drinking after the CS presentation) as a measure of CER strength. This measure varied directly with two of the more important conditioning variables: US (shock) intensity and number of training trials. Since the CS is imposed upon ongoing drinking behavior recovery time is also affected by thirst motivation. Several selected drugs were tested with this procedure. The anxietyreducing benzodiazepines (chlordiazepoxide, diazepam and nitrazepam) and amobarbital produced faster recovery times as compared with controls. In contrast, chlorpromazine produced a non-significant increase in recovery time. The stimulant, d-amphetamine, did not affect the recovery time measure in any significant way. The faster recovery times produced by chlordiazepoxide were shown not to be a result of a state-dependent (dissociated) learning effect or an increase in thirst motivation. It is believed that this simple procedure can be used to investigate drugs (or other variables) that might affect CER strength.

Journal

Psychopharmacology – Springer Journals

Published: Jan 1, 1967

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