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- Publisher
- Springer Journals
- Copyright
- Copyright © 2001 by Kluwer Academic Publishers
- Subject
- Life Sciences; Cardiology; Medical Biochemistry; Oncology; Biochemistry, general
- ISSN
- 0300-8177
- eISSN
- 1573-4919
- DOI
- 10.1023/A:1011044503773
- Publisher site
- See Article on Publisher Site
Abstract
The study addressed, to resolve the role of Receptor-Ck activation in the proteolytic maturation of 125 kDa (membrane bound) sterol regulatory element binding protein (SREBP), revealed that Receptor-Ck dependent signalling is not only responsible for the proteoloytic cleavage of this 125 kDa SREBP resulting in the generation of an active 47 kDa factor but also Receptor-Ck protein has high binding affinity for both 125 kDa SREBP as well as its cleaved 47 kDa product. Based upon these coupled with our earlier findings, we propose that Receptor-Ck may be regulating genes, have sterol regulatory element (SRE) in their promoter region, through the proteolytic maturation of 125 kDa SREBP into an active 47 kDa transcription factor.
Journal
Molecular and Cellular Biochemistry – Springer Journals
Published: Oct 7, 2004