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Andreas Laupacis, C. Gardell, John Dupré, Calvin Stiller, Keown Pa, A. Wallace, P. Thibert (1983)
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125 29 29 4 4 Y. Mori M. Suko Dr. H. Okudaira I. Matsuba A. Tsuruoka A. Sasaki H. Yokoyama T. Tanase T. Shida M. Nishimura E. Terada Y. Ikeda Third Department of Internal Medicine The Jikei University Tokyo Japan Research Center for Rheumatology and Allergy National Sagamihara Hospital Kanagawa Japan Department of Medicine and Physical Therapy The University of Tokyo Tokyo Japan The Animal Institute of Hamamatsu Medical College Shizuoka Japan Laboratory of Life Sciences, School of Hygienic Sciences Kitasato University Kanagawa Japan Summary Non-obese diabetic mice aged 30 to 60 days were treated orally with Cyclosporin at doses of 25,15 and 2.5 mg/kg every 2 days until 160 days of age. Diabetes developed in 12 out of 18 oil-treated mice (67%), with partial to complete Langerhans' islet destruction associated with lymphocytic infiltration. The non-obese diabetic mice showed a plasma glucose concentration of 6.62 ± 0.92 mmol/l (mean ± SD) at 50 days of age. The plasma glucose level of oil-treated non-obese diabetic mice gradually increased after 130 days of age and reached 14.0 to 19.0 mmol/l at 160 days of age, while Cyclosporin-treated non-obese diabetic mice showed neither clear increase of plasma glucose levels nor development of insulitis. The cumulative incidence of diabetes in Cyclosporin-treated mice was significantly lower than that in oil-treated mice ( p < 0.01). Subsequently, Cyclosporin treatment was started after development of glucose intolerance. Twenty-five mg/kg of Cyclosporin was administered every 2 days for 35 days. Cyclosporin appeared to have little therapeutic effect on diabetes in non-obese diabetic mice.
Diabetologia – Springer Journals
Published: Apr 1, 1986
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