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Prevalence and progression of diabetes in mitochondrial disease

Prevalence and progression of diabetes in mitochondrial disease Although patients carrying the m.3243A>G mutation account for the majority of cases of diabetes secondary to mtDNA mutations, several other genotypes are also associated with the development of diabetes, some with high penetrance. All show a gradual progression to insulin requirement. Percentage heteroplasmy is a poor predictor of severity of diabetes in the m.3243A>G group. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetologia Springer Journals

Prevalence and progression of diabetes in mitochondrial disease

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References (21)

Publisher
Springer Journals
Copyright
Copyright © 2007 by Springer-Verlag
Subject
Medicine & Public Health; Human Physiology ; Metabolic Diseases ; Internal Medicine
ISSN
0012-186X
eISSN
1432-0428
DOI
10.1007/s00125-007-0779-9
pmid
17653689
Publisher site
See Article on Publisher Site

Abstract

Although patients carrying the m.3243A>G mutation account for the majority of cases of diabetes secondary to mtDNA mutations, several other genotypes are also associated with the development of diabetes, some with high penetrance. All show a gradual progression to insulin requirement. Percentage heteroplasmy is a poor predictor of severity of diabetes in the m.3243A>G group.

Journal

DiabetologiaSpringer Journals

Published: Oct 1, 2007

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