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Journals Cancer Chemotherapy and Pharmacology Volume 60 Issue 6

A rapid and simple HPLC/UV method for the quantification of noscapine in plasma has been developed to study pharmacokinetics of noscapine at tumor-suppressive doses in the mouse. Since orally available anticancer drugs are rare, therefore, noscapine, an innocuous agent, having a mean oral bioavailability of 31.5% over the studied dose range merits its further advancement in humans for anticancer therapy.

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Preclinical pharmacokinetics and bioavailability of noscapine, a tubulin-binding anticancer agent

More Info
  • Publisher Springer-Verlag
  • Copyright Copyright © 2007 by Springer-Verlag
  • Subject Biomedicine; Oncology ; Pharmacology/Toxicology ; Cancer Research
  • ISSN 0344-5704
  • eISSN 1432-0843
  • D.O.I. 10.1007/s00280-007-0430-y
  • Publisher site Get PDF  

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