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Porcine testicular extract inhibits T cell proliferation by blocking cell cycle transition from G1 phase to S phase

Porcine testicular extract inhibits T cell proliferation by blocking cell cycle transition from... Since T cells express diverse sex steroid hormone receptors, they might be a good model to evaluate the effects of sex steroid hormones on immune modulation. Porcine testicular extract contains several sex steroid hormones and may be useful to study the effects of sex steroid hormones during T cell activation. We have examined the effects of the porcine testicular extract on T cell activation: proliferation and secretion of cytokines (IL-2 and IFN-γ) by activated T cells were severely decreased after treatment with porcine testicular extract. The extract produced an immunosuppressive effect and inhibited the proliferation of activated T cells by blocking the cell cycle transition from the G1 phase to S phase. These effects were mediated by a decrease in the expression of cyclin D1 and cyclin E and constitutive expression of p27KIP1 after T cell activation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biotechnology Letters Springer Journals

Porcine testicular extract inhibits T cell proliferation by blocking cell cycle transition from G1 phase to S phase

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References (21)

Publisher
Springer Journals
Copyright
Copyright © 2012 by Springer Science+Business Media B.V.
Subject
Life Sciences; Applied Microbiology; Biochemistry, general; Biotechnology; Microbiology
ISSN
0141-5492
eISSN
1573-6776
DOI
10.1007/s10529-012-0907-6
pmid
22456900
Publisher site
See Article on Publisher Site

Abstract

Since T cells express diverse sex steroid hormone receptors, they might be a good model to evaluate the effects of sex steroid hormones on immune modulation. Porcine testicular extract contains several sex steroid hormones and may be useful to study the effects of sex steroid hormones during T cell activation. We have examined the effects of the porcine testicular extract on T cell activation: proliferation and secretion of cytokines (IL-2 and IFN-γ) by activated T cells were severely decreased after treatment with porcine testicular extract. The extract produced an immunosuppressive effect and inhibited the proliferation of activated T cells by blocking the cell cycle transition from the G1 phase to S phase. These effects were mediated by a decrease in the expression of cyclin D1 and cyclin E and constitutive expression of p27KIP1 after T cell activation.

Journal

Biotechnology LettersSpringer Journals

Published: Mar 29, 2012

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