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W. Wallis, P. Simkin (1983)
Antirheumatic Drug Concentrations in Human Synovial Fluid and Synovial Tissue Observations on Extravascular PharmacokineticsClinical Pharmacokinetics, 8
W. Schneider, P. Degen (1981)
Simultaneous determination of diclofenac sodium and its hydroxy metabolites by capillary column gas chromatography with electron-capture detection.Journal of chromatography, 217
P. Fowler, M. Shadforth, P. Crook, V. John (2004)
Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long-term treatment of rheumatoid arthritisEuropean Journal of Clinical Pharmacology, 25
R. Menassé, P. Hedwall, J. Kraetz, C. Pericin, L. Riesterer, A. Sallmann, R. Ziel, R. Jaques (1978)
Pharmacological properties of diclofenac sodium and its metabolites.Scandinavian journal of rheumatology. Supplement, 22
228 31 31 4 4 P. D. Fowler P. T. Dawes V. A. John P. A. Shotton Staffordshire Rheumatology Centre The Burslem, Haywood and Tunstall War Memorial Hospital High Lane, Burslem Stoke-on-Trent UK Ciba-Geigy Pharmaceuticals Clinical Pharmacokinetics and Pharmacology Group Wimblehurst Road Horsham UK Summary Plasma and knee joint synovial fluid (SF) concentration of diclofenac sodium and its hydroxylated metabolites were measured after chronic dosing with the 100 mg polymer matrix formulation. Peak concentrations were reached in plasma and SF roughly after administration. Plasma concentrations then fell rapidly, but concentrations in SF were maintained for up to 25 h. The active metabolite was present in both fluids throughout the study period. The slow-release form showed a longer plasma/SF equilibration time than the conventional tablet had in a previous study. Prostaglandin E 1 and F 2 a concentrations were lower in the early post-dose period but did not correlate with drug concentrations.
European Journal of Clinical Pharmacology – Springer Journals
Published: Jul 1, 1986
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