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Plasma and synovial fluid concentrations of diclofenac sodium and its hydroxylated metabolites during once-daily administration of a 100 mg slow-release formulation

Plasma and synovial fluid concentrations of diclofenac sodium and its hydroxylated metabolites... 228 31 31 4 4 P. D. Fowler P. T. Dawes V. A. John P. A. Shotton Staffordshire Rheumatology Centre The Burslem, Haywood and Tunstall War Memorial Hospital High Lane, Burslem Stoke-on-Trent UK Ciba-Geigy Pharmaceuticals Clinical Pharmacokinetics and Pharmacology Group Wimblehurst Road Horsham UK Summary Plasma and knee joint synovial fluid (SF) concentration of diclofenac sodium and its hydroxylated metabolites were measured after chronic dosing with the 100 mg polymer matrix formulation. Peak concentrations were reached in plasma and SF roughly after administration. Plasma concentrations then fell rapidly, but concentrations in SF were maintained for up to 25 h. The active metabolite was present in both fluids throughout the study period. The slow-release form showed a longer plasma/SF equilibration time than the conventional tablet had in a previous study. Prostaglandin E 1 and F 2 a concentrations were lower in the early post-dose period but did not correlate with drug concentrations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Pharmacology Springer Journals

Plasma and synovial fluid concentrations of diclofenac sodium and its hydroxylated metabolites during once-daily administration of a 100 mg slow-release formulation

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References (4)

Publisher
Springer Journals
Copyright
Copyright © 1986 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology
ISSN
0031-6970
eISSN
1432-1041
DOI
10.1007/BF00613526
Publisher site
See Article on Publisher Site

Abstract

228 31 31 4 4 P. D. Fowler P. T. Dawes V. A. John P. A. Shotton Staffordshire Rheumatology Centre The Burslem, Haywood and Tunstall War Memorial Hospital High Lane, Burslem Stoke-on-Trent UK Ciba-Geigy Pharmaceuticals Clinical Pharmacokinetics and Pharmacology Group Wimblehurst Road Horsham UK Summary Plasma and knee joint synovial fluid (SF) concentration of diclofenac sodium and its hydroxylated metabolites were measured after chronic dosing with the 100 mg polymer matrix formulation. Peak concentrations were reached in plasma and SF roughly after administration. Plasma concentrations then fell rapidly, but concentrations in SF were maintained for up to 25 h. The active metabolite was present in both fluids throughout the study period. The slow-release form showed a longer plasma/SF equilibration time than the conventional tablet had in a previous study. Prostaglandin E 1 and F 2 a concentrations were lower in the early post-dose period but did not correlate with drug concentrations.

Journal

European Journal of Clinical PharmacologySpringer Journals

Published: Jul 1, 1986

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