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Pharmacokinetics of sulfametopyrazine (Kelfizine W) effects of a single oral dose

Pharmacokinetics of sulfametopyrazine (Kelfizine W) effects of a single oral dose 228 3 3 1 1 A. Devriendt F. H. Jansen I. Weemaes Department of Paediatrics St. Elisabeth Ziekenhuis Turnhout Belgium Department of Internal Medicine Academisch Ziekenhuis St. Raphaël Leuven Belgium Summary The pharmacokinetics of sulfametopyrazine were studied for seven days after a single oral dose of 2 g. in healthy volunteers in order to establish its chemotherapeutic value. — The appearance and disappearance of the drug in the plasma were evaluated both for compounds with a free amino group and for total sulphonamides. The half-life and absorption, distribution, elimination and excretion coefficients were calculated, as well as the concentrations in plasma water and interstitial fluid. The estimated drug concentrations in the urine agreed with those calculated from the excretion coefficients. — In all subjects at the end of the seventh day the concentrations in all body compartments of active compounds exceeded the minimum required for a therapeutic effect. The highest concentrations found in the urine were always significantly lower than the drug's basal solubility at pH 5, thus excluding any risk of crystalluria. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Pharmacology Springer Journals
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