Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Pharmacokinetics and tissue distribution of PGG–paclitaxel, a novel macromolecular formulation of paclitaxel, in nu/nu mice bearing NCI-460 lung cancer xenografts

Pharmacokinetics and tissue distribution of PGG–paclitaxel, a novel macromolecular formulation of... Incorporation of PTX into the PGG–PTX polymer significantly prolonged the half-life of total taxanes, extractable taxane, and native PTX in both the plasma and tumor compartments. This resulted in a large increase in the amount of active PTX delivered to the tumor. PGG–PTX is an attractive candidate for further development. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Chemotherapy and Pharmacology Springer Journals

Pharmacokinetics and tissue distribution of PGG–paclitaxel, a novel macromolecular formulation of paclitaxel, in nu/nu mice bearing NCI-460 lung cancer xenografts

Loading next page...
 
/lp/springer-journals/pharmacokinetics-and-tissue-distribution-of-pgg-paclitaxel-a-novel-KKKp8YnQn3

References (35)

Publisher
Springer Journals
Copyright
Copyright © 2010 by Springer-Verlag
Subject
Medicine & Public Health; Oncology ; Cancer Research ; Pharmacology/Toxicology
ISSN
0344-5704
eISSN
1432-0843
DOI
10.1007/s00280-009-1058-x
pmid
19593566
Publisher site
See Article on Publisher Site

Abstract

Incorporation of PTX into the PGG–PTX polymer significantly prolonged the half-life of total taxanes, extractable taxane, and native PTX in both the plasma and tumor compartments. This resulted in a large increase in the amount of active PTX delivered to the tumor. PGG–PTX is an attractive candidate for further development.

Journal

Cancer Chemotherapy and PharmacologySpringer Journals

Published: Feb 1, 2010

There are no references for this article.