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Penicillin 70

Penicillin 70 Chemistry of Heterocyclic Compounds, 1Iol. 34, No. 11, 1998 E. Lukevics 1 and G. Veinberg 2 It is 70 years since Nobel prize laureate Sir Alexander Fleming discovered penicillin. Consequently the antibiotic therapy concept based on the medical use of specific toxic metabolites produced by microorganisms in competition with one another in their natural environment has emerged. This event marked the beginning of the antibiotics era which had a revolutionary influence on the cure of infection and cancer. It is well known that penicillin appeared in pharmacy only 15 years after its discovery due to the investigations carried out by USA pharmaceutical companies within the frame of a united giant project. As a result a unique and efficient technology was created based on the employment of such novel approaches as depth fermentation, lyophilization, directed structural biotransformation of antibiotic side chain, etc. which has made this medicine available for wide use. The deciphering of the penicillin structure by X-ray crystallographic analysis permitted explanation of the mecha- nism of its antibacterial action and the mechanism of its inactivation by resistant microorganisms as well~ In the first case transpeptidase is irreversibly inhibited by the formation of a covalent ester bond between penicillin http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemistry of Heterocyclic Compounds Springer Journals

Penicillin 70

Abstract

Chemistry of Heterocyclic Compounds, 1Iol. 34, No. 11, 1998 E. Lukevics 1 and G. Veinberg 2 It is 70 years since Nobel prize laureate Sir Alexander Fleming discovered penicillin. Consequently the antibiotic therapy concept based on the medical use of specific toxic metabolites produced by microorganisms in competition with one another in their natural environment has emerged. This event marked the beginning of the antibiotics era which had a revolutionary influence on the cure of infection...
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Publisher
Springer Journals
Copyright
Copyright © 1999 by Kluwer Academic/Plenum Publishers
Subject
Chemistry; Organic Chemistry; Pharmacy
ISSN
0009-3122
eISSN
1573-8353
DOI
10.1007/BF02256802
Publisher site
See Article on Publisher Site

Abstract

Chemistry of Heterocyclic Compounds, 1Iol. 34, No. 11, 1998 E. Lukevics 1 and G. Veinberg 2 It is 70 years since Nobel prize laureate Sir Alexander Fleming discovered penicillin. Consequently the antibiotic therapy concept based on the medical use of specific toxic metabolites produced by microorganisms in competition with one another in their natural environment has emerged. This event marked the beginning of the antibiotics era which had a revolutionary influence on the cure of infection and cancer. It is well known that penicillin appeared in pharmacy only 15 years after its discovery due to the investigations carried out by USA pharmaceutical companies within the frame of a united giant project. As a result a unique and efficient technology was created based on the employment of such novel approaches as depth fermentation, lyophilization, directed structural biotransformation of antibiotic side chain, etc. which has made this medicine available for wide use. The deciphering of the penicillin structure by X-ray crystallographic analysis permitted explanation of the mecha- nism of its antibacterial action and the mechanism of its inactivation by resistant microorganisms as well~ In the first case transpeptidase is irreversibly inhibited by the formation of a covalent ester bond between penicillin

Journal

Chemistry of Heterocyclic CompoundsSpringer Journals

Published: Nov 4, 2005

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