Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Murphy, N. Sabah (1970)
Spontaneous firing of cerebellar Purkinje cells in decerebrate and barbiturate anesthetized cats.Brain research, 17 3
J. Gilder, J. O'leary (1971)
Effect of Nembutal anesthesia upon Purkinje cell activation in the cat.Electroencephalography and clinical neurophysiology, 30 3
J. Murphy, N. Sabah (1971)
Cerebellar Purkinje cell responses to afferent inputs. I. Climbing fiber activation.Brain research, 25 3
J. Selhorst (1982)
Disorders of the CerebellumJAMA, 247
H. Carrer, Horacio Ferreyra (1980)
Anesthetic-dependent excitability changes in the hypothalamic ventromedial nucleus of the ratExperimental Neurology, 67
S. Bisti, G. Iosif, G. Marchesi, P. Strata (2004)
Pharmacological properties of inhibitions in the cerebellar cortexExperimental Brain Research, 14
D. Burg, F. Rubia (2004)
Inhibition of cerebellar Purkinje cells by climbing fiber inputPflügers Archiv, 337
P. Montarolo, M. Palestini, Piergiorgio Strata (1982)
The inhibitory effect of the olivocerebellar input on the cerebellar Purkinje cells in the rat †The Journal of Physiology, 332
R. Olsen (1982)
Drug interactions at the GABA receptor-ionophore complex.Annual review of pharmacology and toxicology, 22
G. Berlucchi, L. Maffei, G. Moruzzi, P. Strata (1964)
EEG AND BEHAVIORAL EFFECTS ELICITED BY COOLING OF MEDULLA AND PONS.Archives italiennes de biologie, 102
J. Szentágothai, K. Rajkovits (1959)
Über den Ursprung der Kletterfasern des KleinhirnsZeitschrift für Anatomie und Entwicklungsgeschichte, 121
J. Bloedel, W. Roberts (1971)
Action of climbing fibers in cerebellar cortex of the cat.Journal of neurophysiology, 34 1
A. Latham, D. Paul (1971)
Effects of sodium thiopentone on cerebellar neurone activity.Brain research, 25 1
J. Courville, F. Faraco-Cantin (1978)
On the origin of the climbing fibers of the cerebellum. An experimental study in the cat with an autoradiographic tracing methodNeuroscience, 3
(1981)
Effects of inferior olive cooling on the Purkinje cell activity
G. Moore, D. Perkel, J. Segundo (1966)
Statistical analysis and functional interpretation of neuronal spike data.Annual review of physiology, 28
P. Strata (1984)
Recent Aspects of the Function of the Inferior Olive
I. Ho, R. Harris (1981)
Mechanism of action of barbiturates.Annual review of pharmacology and toxicology, 21
R. Llinás, M. Sugimori (1980)
Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices.The Journal of Physiology, 305
P. Strata (1976)
A General Review of the Physiological Function of the Neuronal Machine in the Cerebellar Cortex
F. Roberts, P. Taberner, R. Hill (1978)
The effect of 3-mercaptopropionate, an inhibitor of glutamate decarboxylase, on the levels of GABA and other amino acids, and on presynaptic inhibition in the rat cuneate nucleusNeuropharmacology, 17
P. Strata (1984)
Inferior Olive: Functional Aspects
P. Montarolo, F. Raschi, P. Strata (1979)
Interactions between benzodiazepines and GABA in the cerebellar cortexBrain Research, 162
(1983)
Effects of reversible lesions and stimulation of the inferior olive of fiocculus Purkinje cell activity in the cat
(1980)
The olivoeerebellar system
F. Benedetti, P. Montarolo, S. Rabacchi (2004)
Inferior olive lesion induces long-lasting functional modification in the Purkinje cellsExperimental Brain Research, 55
(1974)
H6ppener U, Langhof H (1974) Lateral inhibition
N. Campbell, D. Armstrong (1983)
The olivocerebellar projection in the rat: An autoradiographic studyBrain Research, 275
J. Bloedel, W. Roberts (1969)
Functional relationship among neurons of the cerebellar cortex in the absence of anesthesia.Journal of neurophysiology, 32 1
(1981)
Electrophysiology of the cerebellar networks. In Brookhart JM, Mountcastle VB (ed) Handbook of Physiology. Sect 1, Vol II, Part 2, The nervous system
Professor Eccles, D. Ito, P. Szentágothai (1967)
The Cerebellum as a Neuronal Machine
R. Llinás, M. Sugimori (1980)
Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices.The Journal of Physiology, 305
E. Costa, A. Guidotti (1979)
Molecular mechanisms in the receptor action of benzodiazepines.Annual review of pharmacology and toxicology, 19
C. Batini, J. Corvisier, J. Destombes, H. Gioanni, J. Everett (1976)
The climbing fibers of the cerebellar cortex, their origin and pathways in catExperimental Brain Research, 26
R. McCarley, J. Hobson (1972)
Simple spike firing patterns of cat cerebellar Purkinje cells in sleep and waking.Electroencephalography and clinical neurophysiology, 33 5
Long term functional changes in the Purkinje cell to climbing fibre deprivation
J. Bloedel (1973)
Cerebellar afferent systems: a review.Progress in neurobiology, 2 1
T. Savio, F. Tempia (1984)
Inferior Olive: Its Tonic Inhibitory Effect on the Cerebellar Purkinje Cells in the Rat Without Anesthesia
P. Strata, P. Montarolo (1982)
Functional aspects of the inferior olive.Archives italiennes de biologie, 120 1-3
A. Latham, D. Paul (1971)
Spontaneous activity of cerebellar Purkinje cells and their responses to impulses in climbing fibresThe Journal of Physiology, 213
F. Rubia, U. Höppener, H. Langhof (1974)
Lateral inhibition of Purkinje cells through climbing fiber afferents?Brain research, 70 1
J. Schulman, F. Bloom (1981)
Golgi cells of the cerebellum are inhibited by inferior olive activityBrain Research, 210
P. Belcari, A. Francesconi, C. Maioli, P. Strata (1977)
Spontaneous activity of the Purkinje cells in the pigeon cerebellumPflügers Archiv, 371
F. Colin, J. Manil, J. Desclin (1980)
The olivocerebellar system. I. Delayed and slow inhibitory effects: An overlooked salient feature of cerebellar climbing fibersBrain Research, 187
(1982)
Effects of suspending climbing fiber activity on the discharge patterns of floccular Purkinje ceils
P. Montarolo, F. Raschi, P. Strata (2004)
Are the climbing fibres essential for the Purkinje cell inhibitory action?Experimental Brain Research, 42
F. Benedetti, P. Montarolo, P. Strata, F. Tempia (1983)
Inferior olive inactivation decreases the excitability of the intracerebellar and lateral vestibular nuclei in the rat.The Journal of Physiology, 340
221 57 57 3 3 T. Savio F. Tempia Istituto di Fisiologia Umana dell'Università C.so Raffaello 30 I-10125 Torino Italy Summary Previous experiments performed in rats under barbiturate anaesthesia have shown a remarkable increase of simple spike firing rate in cerebellar Purkinje cells following inferior olive lesion or inactivation. The increase is due, at least in part, to the withdrawal of the tonic background activity of corticocerebellar interneurones, which have GABA as a chemical transmitter. Since barbiturates potentiate GABAergic inhibition, it is possible that the effect is due to the presence of this type of anaesthesia. In absence of general anaesthesia, we have compared the simple spike firing rate of the Purkinje cells in rats with intact inferior olive and 3–5 days after inferior olive lesion by 3-acetylpyridine. In the latter condition, the firing rate is significantly higher. In other rats, under urethane anaesthesia, which is not known to interfere with GABAergic transmission, the inferior olive has been reversibly inactivated by applying a cooling probe to the ventral surface of the medulla. Following cooling of the inferior olive on one side, a remarkable increase of simple spike activity, parallel to the disappearance of complex spike activity, has been observed in the Purkinje cells of the contralateral side. These results show that the presence of the simple spike firing increase, which follows the removal of the climbing fibre activity, does not depend on an anaesthetic which potentiates GABAergic transmission, although its amplitude is affected by the same anaesthetic. They suggest, therefore, that the tonic inhibition exerted by the olivocerebellar pathway on the Purkinje cells operates also in physiological conditions. By analysing the pattern of discharge of the Purkinje cell simple spikes in intact rats and following suppression of inferior olive activity, we have seen that, in the latter condition, the highest firing rate is accompanied by a higher degree of regularity. This change of pattern does not depend significantly on the removal of an irregularity induced by the complex spikes, but it is mainly the consequence of the firing rate increase.
Experimental Brain Research – Springer Journals
Published: Feb 1, 1985
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.