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Journals Diabetologia Volume 52 Issue 2

These transgenic mice and primary culture techniques provide novel opportunities to interrogate the mechanisms of GIP secretion. Glucose-triggered GIP secretion was SGLT1-dependent and modulated by K ATP channel activity but not determined by sweet taste receptors. Synergistic stimulation by elevated cAMP and glucose suggests that targeting appropriate G-protein-coupled receptors may provide opportunities to modulate GIP release in vivo.

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Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells

H., Parker; A., Habib; G., Rogers; F., Gribble; F., Reimann
Diabetologia , Volume 52 (2)
Springer Journals – Feb 1, 2009

More Info
  • Publisher Springer-Verlag
  • Copyright Copyright © 2009 by Springer-Verlag
  • Subject Medicine & Public Health; Human Physiology ; Metabolic Diseases ; Internal Medicine
  • ISSN 0012-186X
  • eISSN 1432-0428
  • D.O.I. 10.1007/s00125-008-1202-x
  • Publisher site Get PDF  

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