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Neuropharmacological and behavioral evaluation of prostaglandin E 2 and 11-thiol-11-desoxy prostaglandin E 2 in the mouse and rat

Neuropharmacological and behavioral evaluation of prostaglandin E 2 and 11-thiol-11-desoxy... 213 57 57 3 3 James L. Bloss Garry H. Singer Searle Laboratories P.O. Box 5110 60680 Chicago Illinois USA Abstract Prostaglandin E 2 (PGE 2 ) and 11-thiol-11-desoxy Prostaglandin E 2 (SHPGE 2 ) were evaluated in a variety of behavioral and neuropharmacological procedures that are sensitive to neuroleptics. Clozapine (C), thioridazine (T), haloperidol (H), and fluphenazine (F) were also tested for comparison. All agents except T suppressed avoidance responses in trained rats at one or more doses without concurrently disrupting escape behavior. T, H, and F dose-responsively antagonized lesioned rat rotational behavior at nontoxic doses. T, H, and F induced catalepsy at doses considerably higher than those effective on rotational behavior. SHPGE 2 , PGE 2 , and C did not cause catalepsy and did not show statistically significant dose-responsive antagonism of rotational behavior at less than toxic doses. All agents tested blocked d -amphetamine-induced lethality and caused motor incoordination doseresponsively. SHPGE 2 , PGE 2 , C, and T caused statistically significant blockade of physostigmine-induced lethality. H and F were ineffective against physostigmine lethality. It was concluded that SHPGE 2 and PGE 2 demonstrated, qualitatively, a spectrum of neurolepticlike properties remarkably similar to C. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Neuropharmacological and behavioral evaluation of prostaglandin E 2 and 11-thiol-11-desoxy prostaglandin E 2 in the mouse and rat

Bloss, James; Singer, Garry
Psychopharmacology , Volume 57 (3) – Jan 1, 1978
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References (25)

Publisher
Springer Journals
Copyright
Copyright © 1978 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00426754
Publisher site
See Article on Publisher Site

Abstract

213 57 57 3 3 James L. Bloss Garry H. Singer Searle Laboratories P.O. Box 5110 60680 Chicago Illinois USA Abstract Prostaglandin E 2 (PGE 2 ) and 11-thiol-11-desoxy Prostaglandin E 2 (SHPGE 2 ) were evaluated in a variety of behavioral and neuropharmacological procedures that are sensitive to neuroleptics. Clozapine (C), thioridazine (T), haloperidol (H), and fluphenazine (F) were also tested for comparison. All agents except T suppressed avoidance responses in trained rats at one or more doses without concurrently disrupting escape behavior. T, H, and F dose-responsively antagonized lesioned rat rotational behavior at nontoxic doses. T, H, and F induced catalepsy at doses considerably higher than those effective on rotational behavior. SHPGE 2 , PGE 2 , and C did not cause catalepsy and did not show statistically significant dose-responsive antagonism of rotational behavior at less than toxic doses. All agents tested blocked d -amphetamine-induced lethality and caused motor incoordination doseresponsively. SHPGE 2 , PGE 2 , C, and T caused statistically significant blockade of physostigmine-induced lethality. H and F were ineffective against physostigmine lethality. It was concluded that SHPGE 2 and PGE 2 demonstrated, qualitatively, a spectrum of neurolepticlike properties remarkably similar to C.

Journal

Psychopharmacology – Springer Journals

Published: Jan 1, 1978

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