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Nasal congestion after visual sexual stimulation with and without sildenafil (Viagra ® ): a randomized placebo-controlled study

Nasal congestion after visual sexual stimulation with and without sildenafil (Viagra ® ): a... Sildenafil (Viagra ® ) is a selective phosphodiesterase type 5 inhibitor (PDE5-I) approved for treatment of erectile dysfunction. Although relatively well-tolerated, sildenafil is associated with undesired effects including headache, flushing, dyspepsia, nasal congestion, and visual disturbances. In the present study we explored the impact of sildenafil on nasal airway parameters in young potent men. Eleven men (age 26.0 ± 1.8 years) with normal BMI (25.7 ± 0.5) and without nasal respiratory disorders were enrolled in a double-blind, crossover study. All men underwent evaluation of systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), SpO 2 %, acoustic rhinometry, and nasal endoscopy before and after placebo or sildenafil (50 mg) plus visual sexual stimulation (VSS). Nasal examination was performed using 0° rigid telescopes, 4 mm in diameter. A Student’s t test was used for direct comparisons, while the Kruskal–Wallis test (K–W) was utilized for multiple comparisons. After administration of sildenafil plus VSS, the minimum cross sectional area (MCA) was significantly lower that observed with either placebo ( P = 0.03) or sildenafil alone ( P = 0.003). However, the post-stimulation values did not demonstrate any significant differences among the different treatment arms ( P = 0.48; DF = 2; K–W test). In contrast, endonasal volume (VOL) was significantly lower after sildenafil + VSS ( P = 0.01), but not after placebo + VSS ( P = 0.18). None of the other parameters monitored showed any significant variations. Rhinoscopy showed a characteristic increase of the volume of the inferior turbinates, with subjective differences between placebo and sildenafil. These preliminary results suggest that sildenafil reduces nasal volume, and that sexual stimulation may decrease nasal airflow by itself. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Archives of Oto-Rhino-Laryngology Springer Journals

Nasal congestion after visual sexual stimulation with and without sildenafil (Viagra ® ): a randomized placebo-controlled study

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References (18)

Publisher
Springer Journals
Copyright
Copyright © 2008 by Springer-Verlag
Subject
Medicine & Public Health; Head and Neck Surgery; Neurosurgery ; Otorhinolaryngology
ISSN
0937-4477
eISSN
1434-4726
DOI
10.1007/s00405-007-0452-4
pmid
17906871
Publisher site
See Article on Publisher Site

Abstract

Sildenafil (Viagra ® ) is a selective phosphodiesterase type 5 inhibitor (PDE5-I) approved for treatment of erectile dysfunction. Although relatively well-tolerated, sildenafil is associated with undesired effects including headache, flushing, dyspepsia, nasal congestion, and visual disturbances. In the present study we explored the impact of sildenafil on nasal airway parameters in young potent men. Eleven men (age 26.0 ± 1.8 years) with normal BMI (25.7 ± 0.5) and without nasal respiratory disorders were enrolled in a double-blind, crossover study. All men underwent evaluation of systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), SpO 2 %, acoustic rhinometry, and nasal endoscopy before and after placebo or sildenafil (50 mg) plus visual sexual stimulation (VSS). Nasal examination was performed using 0° rigid telescopes, 4 mm in diameter. A Student’s t test was used for direct comparisons, while the Kruskal–Wallis test (K–W) was utilized for multiple comparisons. After administration of sildenafil plus VSS, the minimum cross sectional area (MCA) was significantly lower that observed with either placebo ( P = 0.03) or sildenafil alone ( P = 0.003). However, the post-stimulation values did not demonstrate any significant differences among the different treatment arms ( P = 0.48; DF = 2; K–W test). In contrast, endonasal volume (VOL) was significantly lower after sildenafil + VSS ( P = 0.01), but not after placebo + VSS ( P = 0.18). None of the other parameters monitored showed any significant variations. Rhinoscopy showed a characteristic increase of the volume of the inferior turbinates, with subjective differences between placebo and sildenafil. These preliminary results suggest that sildenafil reduces nasal volume, and that sexual stimulation may decrease nasal airflow by itself.

Journal

European Archives of Oto-Rhino-Laryngology – Springer Journals

Published: Mar 1, 2008

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