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Journals Cellular and Molecular Life Sciences Volume 62 Issue 21

C. D. Harris G. Ermak K. J. A. Davies + 1 213 740 6462 kelvin@usc.edu Ethel Percy Andrus Gerontology Center University of Southern California 3715 McClintock Avenue Los Angeles California 90089-0191 USA Abstract. The DSCR1 ( Adapt78 ) gene 1 is transiently induced by stresses to temporarily protect cells against further potentially lethal challenges. However, chronic expression of the DSCR1 ( Adapt78 ) gene has now been implicated in several pathological conditions including Alzheimer’s disease, Down syndrome and cardiac hypertrophy. Calcipressin 1 has been shown to function through direct binding and inhibition of the serine threonine protein phosphatase Calcineurin. Pharmacological inhibition of calcineurin, by the immunosuppressive drugs cyclosporin A and FK506, affects a wide variety of diseases. It is, therefore, likely that this endogenous calcineurin inhibitor, calcipressin 1, may also play a role in a variety of human diseases.

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Multiple roles of the DSCR1 ( Adapt78 or RCAN1 ) gene and its protein product Calcipressin 1 (or RCAN1) in disease

C., Harris; G., Ermak; K., Davies
Cellular and Molecular Life Sciences , Volume 62 (21)
Springer Journals – Nov 1, 2005

More Info
  • Publisher Birkhäuser-Verlag
  • Copyright Copyright © 2005 by Birkhäuser Verlag, Basel
  • Subject Life Sciences; Life Sciences, general; Biomedicine general; Biochemistry, general; Cell Biology
  • ISSN 1420-682X
  • eISSN 1420-9071
  • D.O.I. 10.1007/s00018-005-5085-4
  • Publisher site Get PDF  

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