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Modulation of avoidance behavior in squirrel monkeys after chronic administration and withdrawal of d -amphetamine or α-methyl-p-tyrosine

Modulation of avoidance behavior in squirrel monkeys after chronic administration and withdrawal... 213 28 28 3 3 Vincent P. Houser Pavlovian Research Laboratory Veterans Administration Hospital 21902 Perry Point MD Abstract Two squirrel monkeys were trained on a nondiscriminated (Sidman) avoidance schedule that presented a conditional aversive stimulus (CAS) whenever the animals failed to respond within 20 sec. Shock was paired with the CAS 20% of the time. A 3 min tone followed by unavoidable shock was superimposed upon this avoidance schedule. Amphetamine (1.0, 2.0 mg/kg) increased responding without consistently affecting shock or CAS rate, while α -methyl-p-tyrosine (150, 225 mg/kg) decreased response rate and led to more CAS presentations and shocks. Withdrawal of amphetamine produced behavioral effects similar in direction but not intensity to those seen after the administration of α -methyl-p-tyrosine. Neither drug reliably altered the facilitation of avoidance response rate normally noted during the 3-min tone. These results were interpreted to reflect the role of the catecholamines in modulating the performance of an avoidance task. Furthermore, an attempt was made to speculate on the mechanism that may be responsible for the behavioral effects noted after the withdrawal of chronic amphetamine administration. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Modulation of avoidance behavior in squirrel monkeys after chronic administration and withdrawal of d -amphetamine or α-methyl-p-tyrosine

Houser, Vincent
Psychopharmacology , Volume 28 (3) – Sep 1, 1973
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References (35)

Publisher
Springer Journals
Copyright
Copyright © 1973 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00429302
Publisher site
See Article on Publisher Site

Abstract

213 28 28 3 3 Vincent P. Houser Pavlovian Research Laboratory Veterans Administration Hospital 21902 Perry Point MD Abstract Two squirrel monkeys were trained on a nondiscriminated (Sidman) avoidance schedule that presented a conditional aversive stimulus (CAS) whenever the animals failed to respond within 20 sec. Shock was paired with the CAS 20% of the time. A 3 min tone followed by unavoidable shock was superimposed upon this avoidance schedule. Amphetamine (1.0, 2.0 mg/kg) increased responding without consistently affecting shock or CAS rate, while α -methyl-p-tyrosine (150, 225 mg/kg) decreased response rate and led to more CAS presentations and shocks. Withdrawal of amphetamine produced behavioral effects similar in direction but not intensity to those seen after the administration of α -methyl-p-tyrosine. Neither drug reliably altered the facilitation of avoidance response rate normally noted during the 3-min tone. These results were interpreted to reflect the role of the catecholamines in modulating the performance of an avoidance task. Furthermore, an attempt was made to speculate on the mechanism that may be responsible for the behavioral effects noted after the withdrawal of chronic amphetamine administration.

Journal

Psychopharmacology – Springer Journals

Published: Sep 1, 1973

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