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S. Boden, D. Davis, T. Dina, J Sunner, S. Wiesel (1992)
Postoperative diskitis: distinguishing early MR imaging findings from normal postoperative disk space changes.Radiology, 184 3
S. Ohtori, G. Inoue, Toshinori Ito, T. Koshi, T. Ozawa, H. Doya, T. Saito, H. Moriya, Kazuhisa Takahashi (2006)
Tumor Necrosis Factor-Immunoreactive Cells and PGP 9.5-Immunoreactive Nerve Fibers in Vertebral Endplates of Patients With Discogenic Low Back Pain and Modic Type 1 or Type 2 Changes on MRISpine, 31
L. Everson (1991)
MRI of the Musculoskeletal System. 2nd edRadiology, 180
P. Schenk, T. Läubli, J. Hodler, A. Klipstein (2006)
Magnetic Resonance Imaging of the Lumbar Spine: Findings in Female Subjects From Administrative and Nursing ProfessionsSpine, 31
C. Leboeuf‐Yde, Per Kjær, T. Bendix, C. Manniche (2008)
Self-reported hard physical work combined with heavy smoking or overweight may result in so-called Modic changesBMC Musculoskeletal Disorders, 9
F. Fayad, M. Lefèvre-Colau, F. Rannou, N. Quintero, A. Nys, Y. Macé, S. Poiraudeau, J. Drapé, M. Revel (2007)
Relation of inflammatory modic changes to intradiscal steroid injection outcome in chronic low back painEuropean Spine Journal, 16
Potchen Ej (1994)
Magnetic resonance imaging of the lumbar spine.The New England Journal of Medicine, 331
Cynthia Peterson, Bryan Gatterman, J. Carter, B. Humphreys, A. Weibel (2007)
Inter- and intraexaminer reliability in identifying and classifying degenerative marrow (Modic) changes on lumbar spine magnetic resonance scans.Journal of manipulative and physiological therapeutics, 30 2
A. Roos, H. Kressel, C. Spritzer, M. Dalinka (1987)
MR imaging of marrow changes adjacent to end plates in degenerative lumbar disk disease.AJR. American journal of roentgenology, 149 3
D. Resnick, G. Niwayama (1978)
Intervertebral disc abnormalities associated with vertebral metastasis: observations in patients and cadavers with prostatic cancer.Investigative radiology, 13 3
MD Kim, S. Lee, Y. Ahn, D. Yoon, C. Lee, S. Lim, A. liation (2007)
Recurrence after Successful Percutaneous Endoscopic Lumbar DiscectomyMinimally Invasive Neurosurgery, 50
Philipp Lang, Neil Chafetz, H. Genant, J. Morris (1990)
Lumbar spinal fusion. Assessment of functional stability with magnetic resonance imaging.Spine, 15 6
P. Kjaer, C. Leboeuf‐Yde, L. Korsholm, J. Sørensen, T. Bendix (2005)
Magnetic Resonance Imaging and Low Back Pain in Adults: A Diagnostic Imaging Study of 40-Year-Old Men and WomenSpine, 30
Alwyn Jones, A. Clarke, B. Freeman, K. Lam, M. Grevitt (2005)
The Modic Classification: Inter- and Intraobserver Error in Clinical PracticeSpine, 30
Johanne St-Arnauld (2009)
The spineZeitschrift fur Orthopadie und ihre Grenzgebiete, 119 6
D. Weishaupt, M. Zanetti, J. Hodler, N. Boos (1998)
MR imaging of the lumbar spine: prevalence of intervertebral disk extrusion and sequestration, nerve root compression, end plate abnormalities, and osteoarthritis of the facet joints in asymptomatic volunteers.Radiology, 209 3
M. Adams, D. McNally, P. Dolan (1996)
'Stress' distributions inside intervertebral discsJournal of Bone and Joint Surgery, American Volume, 78
M. Kuisma, J. Karppinen, J. Niinimäki, M. Kurunlahti, M. Haapea, H. Vanharanta, O. Tervonen (2006)
A Three-Year Follow-up of Lumbar Spine Endplate (Modic) ChangesSpine, 31
M. Modic, P. Steinberg, Jonathan Ross, T. Masaryk, J. Carter (1988)
Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging.Radiology, 166 1 Pt 1
H. Gruber, E. Hanley (2003)
Recent Advances in Disc Cell BiologySpine, 28
A. Saifuddin, P. Renton, B. Taylor (1998)
Effects on the vertebral end-plate of uncomplicated lumbar discography: an MRI studyEuropean Spine Journal, 7
H. Crock (1986)
The Presidential Address: ISSLS: Internal Disc Disruption A Challenge to Disc Prolapse Fifty Years OnSpine, 11
M. Barth, M. Diepers, C. Weiss, C. Thomé (2008)
Two-Year Outcome After Lumbar Microdiscectomy Versus Microscopic Sequestrectomy: Part 2: Radiographic Evaluation and Correlation With Clinical OutcomeSpine, 33
T. Korhonen, J. Karppinen, L. Paimela, A. Malmivaara, K. Lindgren, C. Bowman, A. Hammond, B. Kirkham, S. Järvinen, J. Niinimäki, N. Veeger, M. Haapea, M. Torkki, O. Tervonen, S. Seitsalo, H. Hurri (2006)
The Treatment of Disc Herniation-Induced Sciatica With Infliximab: One-Year Follow-up Results of FIRST II, a Randomized Controlled TrialSpine, 31
G. Schmid, A. Witteler, R. Willburger, C. Kuhnen, M. Jergas, O. Koester (2004)
Lumbar disk herniation: correlation of histologic findings with marrow signal intensity changes in vertebral endplates at MR imaging.Radiology, 231 2
A. Narvani, E. Tsiridis, L. Wilson (2003)
High-Intensity Zone, Intradiscal Electrothermal Therapy, and Magnetic Resonance ImagingJournal of Spinal Disorders & Techniques, 16
M. Adams, B. Freeman, Helen Morrison, I. Nelson, P. Dolan (2000)
Mechanical initiation of intervertebral disc degeneration.Spine, 25 13
F. Williams, N. Manek, P. Sambrook, T. Spector, A. MacGregor (2007)
Schmorl's nodes: common, highly heritable, and related to lumbar disc disease.Arthritis and rheumatism, 57 5
F. Kleinstück, J. Dvořák, A. Mannion (2006)
Are “Structural Abnormalities” on Magnetic Resonance Imaging a Contraindication to the Successful Conservative Treatment of Chronic Nonspecific Low Back Pain?Spine, 31
P. Kjaer, C. Leboeuf‐Yde, J. Sørensen, T. Bendix (2005)
An Epidemiologic Study of MRI and Low Back Pain in 13-Year-Old ChildrenSpine, 30
D. Mitra, V. Cassar‐Pullicino, I. McCall (2004)
Longitudinal study of vertebral type-1 end-plate changes on MR of the lumbar spineEuropean Radiology, 14
Kenneth Lorme (2003)
THE BIOMECHANICS OF BACK PAINChiropractic & Manual Therapies, 11
M. Kuisma, J. Karppinen, J. Niinimäki, R. Ojala, M. Haapea, M. Heliövaara, R. Korpelainen, S. Taimela, A. Natri, O. Tervonen (2007)
Modic Changes in Endplates of Lumbar Vertebral Bodies: Prevalence and Association With Low Back and Sciatic Pain Among Middle-Aged Male WorkersSpine, 32
Charles Girard, M. Schweitzer, W. Morrison, J. Parellada, J. Carrino (2004)
Thoracic spine disc-related abnormalities: longitudinal MR imaging assessmentSkeletal Radiology, 33
M. Modic, T. Masaryk, Jonathan Ross, J. Carter (1988)
Imaging of degenerative disk disease.Radiology, 168 1
T. Toyone, K. Takahashi, H. Kitahara, M. Yamagata, M. Murakami, H. Moriya (1994)
Vertebral bone-marrow changes in degenerative lumbar disc disease. An MRI study of 74 patients with low back pain.The Journal of bone and joint surgery. British volume, 76 5
J. Jarvik, W. Hollingworth, P. Heagerty, D. Haynor, E. Boyko, R. Deyo (2005)
Three-Year Incidence of Low Back Pain in an Initially Asymptomatic Cohort: Clinical and Imaging Risk FactorsSpine, 30
Salla-Maarit Kokkonen, M. Kurunlahti, O. Tervonen, E. Ilkko, H. Vanharanta (2002)
Endplate Degeneration Observed on Magnetic Resonance Imaging of the Lumbar Spine: Correlation with Pain Provocation and Disc Changes Observed on Computed Tomography DiskographySpine, 27
P. Kjaer, L. Korsholm, T. Bendix, J. Sørensen, C. Leboeuf‐Yde (2006)
Modic changes and their associations with clinical findingsEuropean Spine Journal, 15
M. Modic (2007)
Modic type 1 and type 2 changes.Journal of neurosurgery. Spine, 6 2
J. Vital, O. Gille, V. Pointillart, Massoud Pedram, P. Bacon, F. Razanabola, C. Schaelderle, S. Azzouz (2003)
Course of Modic 1 Six Months After Lumbar Posterior OsteosynthesisSpine, 28
E. Carragee, Todd Alamin, Jonothan Miller, John Carragee (2005)
Discographic, MRI and psychosocial determinants of low back pain disability and remission: a prospective study in subjects with benign persistent back pain.The spine journal : official journal of the North American Spine Society, 5 1
Dominik Weishaupt, M. Zanetti, J. Hodler, Bruno Fuchs, C. Pfirrmann, N. Boos (2001)
Painful Lumbar Disk Derangement: Relevance of Endplate Abnormalities at MR Imaging.Radiology, 218 2
Virginie Hoenen-Clavert, A. Rat, D. Loeuille, I. Bettembourg-Brault, Christine Michel-Batôt, A. Blum, J. Pourel, I. Chary-Valckenaere (2007)
Inflammatory and structural evaluation in spondyloarthritis: magnetic resonance imaging analysis of axial and peripheral involvement.The Journal of rheumatology, 34 4
R. Deyo, M. Ciol, D. Cherkin, J. Loeser, S. Bigos (1993)
Lumbar spinal fusion. A cohort study of complications, reoperations, and resource use in the Medicare population.Spine, 18 11
G. Buttermann, K. Heithoff, J. Ogilvie, E. Transfeldt, M. Cohen (2005)
Vertebral body MRI related to lumbar fusion resultsEuropean Spine Journal, 6
J. Burke, Orthopaedics Watson, M. Walsh, Orthopaedic Mccormack, J. Surgeon, Fitzpatrick, R. Watson, D. McCormack, F. Dowling, J. Fitzpatrick (2002)
Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators.The Journal of bone and joint surgery. British volume, 84 2
J. Ulmer, A. Elster, V. Mathews, A. Allen (1995)
Lumbar spondylolysis: reactive marrow changes seen in adjacent pedicles on MR images.AJR. American journal of roentgenology, 164 2
J. Cavanaugh, Ozaktay Ac, T. Yamashita, A. Avramov, T. Getchell, A. King (1997)
Mechanisms of low back pain: a neurophysiologic and neuroanatomic study.Clinical orthopaedics and related research, 335
G. Waddell (1987)
1987 Volvo Award in Clinical Sciences: A New Clinical Model for the Treatment of Low-Back PainSpine, 12
C. Peterson, B. Humphreys, Tania Pringle (2007)
Prevalence of modic degenerative marrow changes in the cervical spine.Journal of manipulative and physiological therapeutics, 30 1
T. Masaryk, F. Boumphrey, M. Modic, Cynthia Tamborrello, Jonathan Ross, Mark Brown (1986)
Effects of Chemonucleolysis Demonstrated by MR ImagingJournal of Computer Assisted Tomography, 10
O. Beşalti, Z. Pekcan, Y. Sirin, G. Erbaş (2006)
Magnetic resonance imaging findings in dogs with thoracolumbar intervertebral disk disease: 69 cases (1997-2005).Journal of the American Veterinary Medical Association, 228 6
M. Modic, D. Feiglin, D. Piraino, F. Boumphrey, M. Weinstein, P. Duchesneau, S. Rehm (1985)
Vertebral osteomyelitis: assessment using MR.Radiology, 157 1
M. Barth, C. Weiss, C. Thomé (2008)
Two-Year Outcome After Lumbar Microdiscectomy Versus Microscopic Sequestrectomy: Part 1: Evaluation of Clinical OutcomeSpine, 33
T. Jensen, J. Sørensen, P. Kjaer (2007)
Intra- and interobserver reproducibility of vertebral endplate signal (Modic) changes in the lumbar spine: the nordic modic consensus group classificationActa Radiologica, 48
F. Rannou, W. Ouanes, I. Boutron, B. Lovisi, F. Fayad, Y. Macé, D. Borderie, H. Guérini, S. Poiraudeau, M. Revel (2007)
High-sensitivity C-reactive protein in chronic low back pain with vertebral end-plate Modic signal changes.Arthritis and rheumatism, 57 7
MA Adams (2004)
Biomechanics of back painAcupunct Med, 22
L. Marshman, M. Trewhella, T. Friesem, C. Bhatia, M. Krishna (2007)
Reverse transformation of Modic type 2 changes to Modic type 1 changes during sustained chronic low-back pain severity. Report of two cases and review of the literature.Journal of neurosurgery. Spine, 6 2
Michael Shen, Afshin Razi, J. Lurie, B. Hanscom, J. Weinstein (2007)
Retrolisthesis and lumbar disc herniation: a preoperative assessment of patient function.The spine journal : official journal of the North American Spine Society, 7 4
M. Adams, D. McNally, P. Dolan (1996)
'Stress' distributions inside intervertebral discs. The effects of age and degeneration.The Journal of bone and joint surgery. British volume, 78 6
Crock Hv (1970)
A REAPPRAISAL OF INTERVERTEBRAL DISC LESIONSMedical Journal of Australia, 1
C. Chung, B. Berg, T. Tavernier, A. Cotten, J. Laredo, C. Vallée, J. Malghem (2004)
End plate marrow changes in the asymptomatic lumbosacral spine: frequency, distribution and correlation with age and degenerative changesSkeletal Radiology, 33
T. Hansson, B. Roos (1981)
Microcalluses of the Trabeculae in Lumbar Vertebrae and Their Relation to the Bone Mineral ContentSpine, 6
HV Crock (1986)
Internal disc disruption: a challenge to disc prolapse fifty years onSpine, 11
M. Putzier, S. Schneider, J. Funk, S. Tohtz, C. Perka (2005)
The Surgical Treatment of the Lumbar Disc Prolapse: Nucleotomy With Additional Transpedicular Dynamic Stabilization Versus Nucleotomy AloneSpine, 30
G. Buttermann (2004)
The effect of spinal steroid injections for degenerative disc disease.The spine journal : official journal of the North American Spine Society, 4 5
M. Karchevsky, M. Schweitzer, J. Carrino, Adam Zoga, D. Montgomery, L. Parker (2005)
Reactive endplate marrow changes: a systematic morphologic and epidemiologic evaluationSkeletal Radiology, 34
Douglas Beaman, Gregory Graziano, Roy Glover, E. Wojtys, Virginia Chang (1993)
Substance P innervation of lumbar spine facet joints.Spine, 18 8
I. Braithwaite, J. White, A. Saifuddin, P. Renton, B. Taylor (1998)
Vertebral end-plate (Modic) changes on lumbar spine MRI: correlation with pain reproduction at lumbar discographyEuropean Spine Journal, 7
H. Albert, C. Manniche (2007)
Modic changes following lumbar disc herniationEuropean Spine Journal, 16
H. Sandhu, Luis Sanchez-Caso, Hari Parvataneni, F. Cammisa, F. Girardi, Bernard Ghelman (2000)
Association between findings of provocative discography and vertebral endplate signal changes as seen on MRI.Journal of spinal disorders, 13 5
H. Albert, P. Kjaer, T. Jensen, J. Sørensen, T. Bendix, C. Manniche (2008)
Modic changes, possible causes and relation to low back pain.Medical hypotheses, 70 2
Modic changes (MC) are a common phenomenon on magnetic resonance imaging (MRI) in spinal degenerative diseases and strongly linked with low back pain (LBP). Histology, radiology, potential mechanisms, natural history and clinical studies of MC has formed the foundation on which our understanding of spinal degenerative diseases is built. The objective of this study was to provide a review of recent important advances in the study of MC and their clinical significance. This review article summarizes these studies, by delineating the possible mechanisms, and raising doubts and new questions. The related aspects such as discography and differential diagnosis with spinal infection and tumor on MRI are also discussed. Although most of researchers believe that MC are common findings in patients with spinal degenerative diseases and have an association with discogenic LBP, different results between studies may be produced from the differences in study design, inclusion criteria, and sample size. How the present knowledge of MC affects the management of spinal degenerative diseases remains unclear. Further studies of MC will explore therapeutic possibilities for future treatments of spinal degenerative diseases.
European Spine Journal – Springer Journals
Published: Oct 1, 2008
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