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Modern Trends in Research and Development of Antiasthmatic and Antiallergic Drugs

Modern Trends in Research and Development of Antiasthmatic and Antiallergic Drugs Pharmaceutical Chemistry Journal Vol. 37, No. 6, 2003 SEARCH FOR NEW DRUGS MODERN TRENDS IN RESEARCH AND DEVELOPMENT OF ANTIASTHMATIC AND ANTIALLERGIC DRUGS 1 1 2 V. L. Kovaleva, E. V. Shilova, and V. V. Poroikov Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 37, No. 6, pp. 16 – 20, June, 2003. Original article submitted February 23, 2002. Progress achieved in the last 15 years in the pharmaco- gic pneumonia in B6D2F1 mice showed that T lymphocytes therapy of bronchial asthma (BA) and other allergic disor- migrating toward lungs in response to a challenging dose of ders is related primarily to the development of new medici- the antigen are necessary for the local production of IL-4 and nal forms of the well-known bronchodilators and glucocorti- IL-5 (determining the direction of B and T lymphocyte de- costeroids (for intranasal, inhalation, and peroral velopment and the activation and differentiation of administration with prolonged release). Essentially new eosinophils), whereby the CD4 + T type lymphocytes be- preparations implemented into pulmonological practice in- longed to the CD44 + CD45Rblo phenotype [2]. clude inhibitors and antagonists of leukotrienes (see Table 1), In this context, it is quite reasonable that the leading but their therapeutic efficacy has http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Chemistry Journal Springer Journals

Modern Trends in Research and Development of Antiasthmatic and Antiallergic Drugs

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References (9)

Publisher
Springer Journals
Copyright
Copyright © 2003 by Plenum Publishing Corporation
Subject
Pharmacy; Pharmacology/Toxicology; Organic Chemistry; Pharmacy
ISSN
0091-150X
eISSN
1573-9031
DOI
10.1023/A:1026097529934
Publisher site
See Article on Publisher Site

Abstract

Pharmaceutical Chemistry Journal Vol. 37, No. 6, 2003 SEARCH FOR NEW DRUGS MODERN TRENDS IN RESEARCH AND DEVELOPMENT OF ANTIASTHMATIC AND ANTIALLERGIC DRUGS 1 1 2 V. L. Kovaleva, E. V. Shilova, and V. V. Poroikov Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 37, No. 6, pp. 16 – 20, June, 2003. Original article submitted February 23, 2002. Progress achieved in the last 15 years in the pharmaco- gic pneumonia in B6D2F1 mice showed that T lymphocytes therapy of bronchial asthma (BA) and other allergic disor- migrating toward lungs in response to a challenging dose of ders is related primarily to the development of new medici- the antigen are necessary for the local production of IL-4 and nal forms of the well-known bronchodilators and glucocorti- IL-5 (determining the direction of B and T lymphocyte de- costeroids (for intranasal, inhalation, and peroral velopment and the activation and differentiation of administration with prolonged release). Essentially new eosinophils), whereby the CD4 + T type lymphocytes be- preparations implemented into pulmonological practice in- longed to the CD44 + CD45Rblo phenotype [2]. clude inhibitors and antagonists of leukotrienes (see Table 1), In this context, it is quite reasonable that the leading but their therapeutic efficacy has

Journal

Pharmaceutical Chemistry JournalSpringer Journals

Published: Oct 7, 2004

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