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Pharmaceutical Chemistry Journal Vol. 37, No. 6, 2003 SEARCH FOR NEW DRUGS MODERN TRENDS IN RESEARCH AND DEVELOPMENT OF ANTIASTHMATIC AND ANTIALLERGIC DRUGS 1 1 2 V. L. Kovaleva, E. V. Shilova, and V. V. Poroikov Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 37, No. 6, pp. 16 – 20, June, 2003. Original article submitted February 23, 2002. Progress achieved in the last 15 years in the pharmaco- gic pneumonia in B6D2F1 mice showed that T lymphocytes therapy of bronchial asthma (BA) and other allergic disor- migrating toward lungs in response to a challenging dose of ders is related primarily to the development of new medici- the antigen are necessary for the local production of IL-4 and nal forms of the well-known bronchodilators and glucocorti- IL-5 (determining the direction of B and T lymphocyte de- costeroids (for intranasal, inhalation, and peroral velopment and the activation and differentiation of administration with prolonged release). Essentially new eosinophils), whereby the CD4 + T type lymphocytes be- preparations implemented into pulmonological practice in- longed to the CD44 + CD45Rblo phenotype [2]. clude inhibitors and antagonists of leukotrienes (see Table 1), In this context, it is quite reasonable that the leading but their therapeutic efficacy has
Pharmaceutical Chemistry Journal – Springer Journals
Published: Oct 7, 2004
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