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- Publisher
- Springer Journals
- Copyright
- Copyright © 2009 by Springer Science+Business Media, Inc.
- Subject
- Biomedicine; Laboratory Medicine ; Pathology ; Cell Biology; Internal Medicine ; Biomedicine general
- ISSN
- 0007-4888
- eISSN
- 1573-8221
- DOI
- 10.1007/s10517-009-0611-2
- Publisher site
- See Article on Publisher Site
Abstract
Muscular dystrophy is a common multisystem disease, which results from the impairment of alternative splicing. An increase in the number of unstable CTG and CCTG repeats in untranslated regions of the DMPK and ZNF9 genes is followed by dysregulation of RNA-binding proteins. Further changes are followed by dysfunction of insulin receptors, membrane Cl- channels, and other proteins. We developed a new mathematical model for the regulation of splicing of exon 11 in the IR gene, which describes the effect of various factors on alternative splicing.
Journal
Bulletin of Experimental Biology and Medicine – Springer Journals
Published: Oct 30, 2009