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Microcalorimetric Study of Tetrahymena Growth Affected by Copper(II) Complexes

Microcalorimetric Study of Tetrahymena Growth Affected by Copper(II) Complexes By means of microcalorimetry, the effect of four copper(II) complexes on Tetrahymena growth was investigated. The extent and duration of the inhibitory effect on the metabolism, judged by the rate constant, k, and the half inhibition concentration, IC50, varied with the different complexes. The results showed that the half inhibition concentrations IC50 of CuCl2, (C9H6NO)2Cu and [Cu(phen)2]Cl2⋅6H2O were 9.9 × 10−4, 2.0 × 10−4, and 2.6 × 10−4 mol/L, respectively. The sequence of antibiotic activity of these three complexes was: (C9H6NO)2Cu > [Cu(phen)2]Cl2⋅6H2O > CuCl2. The growth rate constants of [Cu(phen)3]Cl2⋅6H2O did not change obviously with the increase of concentrations, but [Cu(phen)3]Cl2⋅6H2O also can prolong the time of Tetrahymena growth. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biological Trace Element Research Springer Journals

Microcalorimetric Study of Tetrahymena Growth Affected by Copper(II) Complexes

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References (22)

Publisher
Springer Journals
Copyright
Copyright © 2009 by Humana Press Inc.
Subject
Life Sciences; Oncology ; Nutrition; Biotechnology; Biochemistry, general
ISSN
0163-4984
eISSN
1559-0720
DOI
10.1007/s12011-009-8558-8
pmid
19911118
Publisher site
See Article on Publisher Site

Abstract

By means of microcalorimetry, the effect of four copper(II) complexes on Tetrahymena growth was investigated. The extent and duration of the inhibitory effect on the metabolism, judged by the rate constant, k, and the half inhibition concentration, IC50, varied with the different complexes. The results showed that the half inhibition concentrations IC50 of CuCl2, (C9H6NO)2Cu and [Cu(phen)2]Cl2⋅6H2O were 9.9 × 10−4, 2.0 × 10−4, and 2.6 × 10−4 mol/L, respectively. The sequence of antibiotic activity of these three complexes was: (C9H6NO)2Cu > [Cu(phen)2]Cl2⋅6H2O > CuCl2. The growth rate constants of [Cu(phen)3]Cl2⋅6H2O did not change obviously with the increase of concentrations, but [Cu(phen)3]Cl2⋅6H2O also can prolong the time of Tetrahymena growth.

Journal

Biological Trace Element Research – Springer Journals

Published: Nov 13, 2009

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