Access the full text.
Sign up today, get DeepDyve free for 14 days.
K. Southgate, Michael Fisher, A. Banning, V. Thurston, A. Baker, R. Fabunmi, P. Groves, M. Davies, A. Newby (1996)
Upregulation of basement membrane-degrading metalloproteinase secretion after balloon injury of pig carotid arteries.Circulation research, 79 6
S. Tyagi, L. Meyer, R. Schmaltz, H. Reddy, D. Voelker (1995)
Proteinases and restenosis in the human coronary artery: extracellular matrix production exceeds the expression of proteolytic activity.Atherosclerosis, 116 1
D. Todor, Isabel Lewis, Gerry Bruno, Douglas Chyatte (1998)
Identification of a serum gelatinase associated with the occurrence of cerebral aneurysms as pro-matrix metalloproteinase-2.Stroke, 29 8
Z. Galis, G. Sukhova, M. Lark, P. Libby (1994)
Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.The Journal of clinical investigation, 94 6
J. Russell, S. Graham, M. Richardson (1998)
Cardiovascular disease in the JCR:LA-cp ratMolecular and Cellular Biochemistry, 188
Z. Galis, M. Muszynski, G. Sukhova, Elissa Simon-Morrissey, E. Unemori, M. Lark, E. Amento, P. Libby (1994)
Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion.Circulation research, 75 1
A. Newby, A. Zaltsman (1999)
Fibrous cap formation or destruction--the critical importance of vascular smooth muscle cell proliferation, migration and matrix formation.Cardiovascular research, 41 2
M. Richardson, A. Schmidt, S. Graham, B. Achen, M. Dereske, J. Russell (1997)
Vasculopathy and insulin resistance in the JCR:LA-cp rat.Atherosclerosis, 138 1
S. Schwartz, D. Deblois, E. O’Brien (1995)
The intima. Soil for atherosclerosis and restenosis.Circulation research, 77 3
Z. Galis, M. Muszynski, G. Sukhova, Elissa Simon-Morrissey, P. Libby (1994)
Enhanced Expression of Vascular Matrix Metalloproteinases Induced In Vitro by Cytokines and in Regions of Human Atherosclerotic Lesions aAnnals of the New York Academy of Sciences, 748
L. Saward, P. Zahradka (2004)
Coronary artery smooth muscle in culture: migration of heterogeneous cell populations from vessel wallMolecular and Cellular Biochemistry, 176
A. Zaltsman, A. Newby (1997)
Increased secretion of gelatinases A and B from the aortas of cholesterol fed rabbits: relationship to lesion severity.Atherosclerosis, 130 1-2
ZS Galis, M Muszynski, GK Sukhova, E Simon-Morrissey, P Libby (1995)
Enhanced expression of vascular matrix metalloproteinases induced in vitro by cytokines and in regions of human atherosclerotic lesionsAnn NY Acad Sci, 748
S. Tyagi, L. Matsubara, K. Weber (1993)
Direct extraction and estimation of collagenase(s) activity by zymography in microquantities of rat myocardium and uterus.Clinical biochemistry, 26 3
M. Bond, R. Fabunmi, A. Baker, A. Newby (1998)
Synergistic upregulation of metalloproteinase‐9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF‐κBFEBS Letters, 435
Richard Lee, F. Schoen, H. Loree, M. Lark, P. Libby (1996)
Circumferential stress and matrix metalloproteinase 1 in human coronary atherosclerosis. Implications for plaque rupture.Arteriosclerosis, thrombosis, and vascular biology, 16 8
R. Pauly, A. Passaniti, C. Bilato, R. Monticone, L. Cheng, N. Papadopoulos, Yehezkiel Gluzband, L. Smith, C. Weinstein, E. Lakatta (1994)
Migration of cultured vascular smooth muscle cells through a basement membrane barrier requires type IV collagenase activity and is inhibited by cellular differentiation.Circulation research, 75 1
R. Fabunmi, A. Baker, E. Murray, R. Booth, A. Newby (1996)
Divergent regulation by growth factors and cytokines of 95 kDa and 72 kDa gelatinases and tissue inhibitors or metalloproteinases-1, -2, and -3 in rabbit aortic smooth muscle cells.The Biochemical journal, 315 ( Pt 1)
Clinically significant occlusive vascular lesions contain more extracellular matrix (ECM) proteins and lipid deposition than healthy vascular tissue. The events leading to this condition remain unresolved. One possibility is that ECM deposition may exceed ECM degradation which would contribute to the expansion of the vascular lesion. Utilizing lean (+/?) and insulin-resistant, corpulent (cp/cp) JCR:LA-cp rats, which are predisposed to develop vascular lesions, we have compared the matrix metalloproteinase (MMP) profile prior to the development of significant vascular lesions. Analysis of serum MMPs revealed that cp/cp rats have lower circulating levels than (+/?) controls. This is observed prior to the development of any noticeable atherosclerotic lesions. It also occurs as the hyperinsulinemia and insulin resistance is first developing in these rats. Female corpulent animals, which are less prone to develop vascular lesions, also exhibit a depressed serum MMP profile of a similar magnitude to their male counterparts. Primary vascular smooth muscle cells isolated from cp/cp animals also showed a reduction in secreted MMP compared with cells derived from +/? lean controls. We conclude that reduced MMP levels could lead to increased ECM accumulation and thus contribute to early vascular lesion formation.
Molecular and Cellular Biochemistry – Springer Journals
Published: Oct 7, 2004
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.